黏蛋白和转化生长因子βⅡ型受体在胃癌组织中的表达及其意义

Significance of the expression of MUC4 and TGF-βRⅡ in gastric carcinomas

目的探讨黏蛋白(MUC4)和转化生长因子βⅡ型受体(TGF-βRⅡ)在胃癌组织中的表达及其与生物学行为之间的关系。方法应用免疫组化S-P法检测87例胃癌标本中MUC4和TGF-βRⅡ的表达。结果MUC4在胃癌组织中表达阳性率为95.4%(83/87),与组织分化、肿瘤浸润深度及淋巴结转移密切相关(P<0.05);TGF-βRⅡ在胃癌组织中表达阳性率为16.1%(14/87),与组织分化、肿瘤浸润深度密切相关(P<0.05);两者的表达与患者年龄、性别均无关(P!0.05);而且MUC4与TGF-βRⅡ的表达之间呈负相关(P<0.01)。结论MUC4与TGF-βRⅡ的表达是研究胃癌不同组织分化的较好指标,TGF-βRⅡ的低表达可能引起MUC4的高表达,促使肿瘤的浸润和转移。

[Objective] To investigate the significance of MUC4 and TGF-βRⅡ expression in gastric carcinoms.[Methods] MUC4 and TGF-βRⅡ were detected by immunohistochemistry in 87 patients with gastric carcinoma [Results] In 87 cases of gastric carcinoma,83(95.4%)were positive for MUC4 protein,and 14(16.1%)were TGF-βRⅡ positive.The expression of MUC4 was strongly related to the tissue differentiations,depth of invasion,and lymph nodes metastasis of gastric carcinoms(P <0.05).The expression of TGF-βRⅡ was strongly related to the tissue differentiations and depth of invasion of gastric carcinoms(P <0.05).However,MUC4 and TGF-βRⅡ had no significant difference with patients' age and gender(P >0.05).There was negative relationship between expressions of MUC4 and TGF-βRⅡ(P <0.01).[Conclusion] MUC4 and TGF-βRⅡ may be good markers for tissue differentiations of gastric carcinoms,and low expression of TGF-βRⅡ may induce expression of MUC4 and then contribute to the invasion and metastasis of gastric carcinoms.