综合重症监护病房主要致病菌的菌群分布及其药敏分析

Major Pathogenic Bacteria Distribution in Comprehensive ICU and Analysis of Corresponding Drug Sensitivity

目的:了解我院综合重症监护病房主要致病菌的菌群分布及其耐药性状况,为危重患者抗菌药物的合理应用提供依据。方法:对我院ICU 2001年1月至2004年12月所分离致病菌的菌群分布及耐药情况进行回顾性分析。结果:455例标本进行细菌培养,阳性279例。其中阳性率最高的是大肠埃希菌53例次,其它依次是铜绿假单胞菌50例次、金葡菌46例次、白假丝酵母菌33例次和阴沟肠杆菌11例次等。革兰阴性致病杆菌对亚胺培南、头孢哌酮和(或)舒巴坦、头孢他啶敏感性较高;革兰阳性致病球菌对万古霉素、替考拉宁、氯霉素、利福平的敏感性较高。结论:熟悉ICU主要致病菌的菌群分布及其耐药性状况非常重要,对危重感染患者早期合理经验性选用抗菌药物、提高危重病患者救治成功率具有重要意义。

Objective:To explore the distribution of major pathogenic bacteria in our comprehensive ICU and the condition of drug tolerance,to supply reasonable applied evidence of antibiotic drugs for intensive patients.Methods:To analysis the distribution of major pathogenic bacteria and the condition of drug tolerance in the comprehensiv ICU from January 2001 to December 2004 retrospectively.Results: 279 samples showed positive of total 455 ones undergoing bacterial culture.The most frequent positive sample was Escherichia coli(53 samples),followed by Pseudomonas aeruginosa(50 samples),Staphylococcus aureus (46 samples),Candida albicans(33 samples) and Aerobacter cloacae(11 samples). Gram-negative pathogenic bacillus showed sensitivity to Imipenem,Cefoperazone/ Sulbactam and Ceftazidime.Gram-positive pathogenic coccus was sensitive to Vancomycin,Teicoplanin,Chloramphenicol and Rifampicin.Conclusions:It's essential to familiarize the distribution of major pathogenic bacteria in ICU and drug tolerance condition,which plays a significant role on the early reasonable application of antibiotics and on the successful rescue for intensive infectious patients.