瑞芬太尼控制性降压用于脊柱手术的临床研究被引量：2

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摘要目的与硝酸甘油对比研究瑞芬太尼控制性降压用于脊柱手术的安全有效性.方法选择全麻下行脊柱锥体骨折经后路切开复位内固定植骨融合术患者30例,随机分为瑞芬太尼组(R组)和硝酸甘油组(N组),每组15例.静脉复合全身麻醉,手术进入骨质操作后行控制性降压,降压目标为MAP60～65mmHg.R组以瑞芬太尼2μg/kg静注,0.1～0.5μg穔g-1穖in-1微量泵维持.N组以硝酸甘油2μg/kg静注,0.5～3μg穔g-1穖in-1微量泵维持.降压60min后停止降压.记录MAP、HR、CVP;术中失血量、手术时间、手术结束至拔除气管导管时间.结果两组病人的性别、年龄、体重、手术时间、拔管时间差异无显著意义,术中出血量R组显著少于N组(P＜0.01).实施控制性降压后两组病人的MAP均达到预定目标,MAP下降均显著低于降压前(P＜0.01).R组停止降压10min后、N组停止降压30min后MAP恢复至降压前.降压期间R组的HR显著低于降压前(P＜0.05,P＜0.01),停止降压10min恢复至降压前.N组降压15min后至停止降压30minHR显著高于降压前(P＜0.05,P＜0.01).降压开始15min内R组的CVP与降压前相比差异无显著意义;N组的CVP显著低于降压前(P＜0.05,P＜0.01).结论脊柱手术中瑞芬太尼控制性降压安全、有效、易于调控.与硝酸甘油相比,瑞芬太尼降压更平稳,对CVP影响小,不影响病人术羊清醒拔管,是全麻手术行控制性降压较好的选择药物.

作者戚劭

机构地区宁夏平罗县人民医院麻醉科

出处《中外医疗》 2007年第24期33-34,共2页 China & Foreign Medical Treatment

关键词瑞芬太尼控制性降压脊柱手术硝酸甘油

分类号 R97 [医药卫生—药品]

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