期刊文献+

初治活动性肺结核T淋巴细胞亚群检测及其临床意义 被引量:4

下载PDF
导出
摘要 目的观察肺结核患者血清中T淋巴细胞亚群变化,探讨其免疫状态改变的临床意义。方法采用流式细胞术检测89例初治活动性肺结核患者外周血T淋巴细胞亚群CD3+、CD4+、CD8+并结合临床资料进行分析。结果与健康对照组比较,初治活动性肺结核患者外周血CD4+、CD4+/CD8+显著降低,而CD8+差异不显著;与血清结核抗体阴性者相比,结核抗体阳性者CD4+、CD4+/CD8+显著降低;T细胞亚群变化与排菌状态及病变范围无明显关联。结论单纯T淋巴细胞亚群计数检测虽然在一定程度上反映了机体的免疫状况,但不能作为判断病情变化及预后的主要依据。
出处 《现代医学》 2007年第6期468-470,共3页 Modern Medical Journal
  • 相关文献

参考文献7

  • 1肺结核诊断和治疗指南[J].中华结核和呼吸杂志,2001,24(2):70-74. 被引量:2864
  • 2立彦,王自正.肺结核病人治疗前后T细胞亚群的变化[J].放射免疫学杂志,2006,19(6):543-544. 被引量:4
  • 3[3]Tsao T C,Chen C H,Hong J H,et al.Shifts of T4/T8 T lymphocytes from BAL fluid and peripheral blood by clinical grade in patients with pulmonary tuberculosis[J].Chest,2002,122 (4):1285-1291.
  • 4[4]Namba Y,Jegasothy B V,Waksman B H.Regulatory substances produced by lymphocytes:V.production of inhibitor of DNA synthesis (IDS) by proliferating pT lymphocytes[J].J Immunol,1977,118 (4):1379 -1384.
  • 5[5]Lienhardt C,Azzurri A,Amedei A,et al.Active tuberculosis in Africa is associated with reduced Th1 and increased Th2 activity in vivo[J].Eur J Immunol,2002,32 (6):1605-1613.
  • 6[6]Ostanin A A,Khonina N A,Norkin M N,et al.T Cell functional disturbances in patients with pulmonary tuberculosis[J].Russ J Immunol,2000,5 (1):53-62.
  • 7[7]Toossi Z,Kleinhenz M E,Ellner J J.Defective interleukin 2 production and responsiveness in human pulmonary tuberculosis[J].J Exp Med,1986,163(5):1162-1172.

二级参考文献3

共引文献2865

同被引文献23

  • 1Deveci F, Akbulut HH, Celik I, Maz MH, Ilhan F. Lymphocyte subpopulations in pulmonary tuberculosis patients[J]. Mediators inflamm,2006, 2006(2): 1-6.
  • 2曾定国,王南华.现代实用结核病学[M].北京:科学技术文出版社,2003:293-298.
  • 3黄建飞.肺结核合并糖尿病治疗进展[J].中国药物经济学,2013,(2):365-368.
  • 4RUHWALD M, DOMINGUE Z J, LATORRE I, et al. A muhi- centre evaluation of the accuracy and performance of IP-10 for the diagnosis of infection with M. tuberculosis [ J ]. Tuberculo- sis,2011,91 (3) :260-267.
  • 5LATORRE I, DIAZ J, MIALDEA I, et al. IP-10 is an accurate biomarker for the diagnosis of tuberculosis in children [ J ]. In- fect ,2014,69 (6) :590-599.
  • 6KIBIK! G S,MYERS L C,KALAMBO C F,et al. Bronchoalve- olar neutro- phils, interferon gamma- inducible protein 10 and interleukin-7 in AIDS- associated tuberculosis [ J ]. CIin ExP Immunol, 2007,148 ( 2 ) : 254 - 259.
  • 7KABEER B S, SIKHAMANI R, RAJA A, et al. Comparison of interferon gamma and interferon gamma- inducible protein- 10 secretion in HIV- tuberculosis patients [ J ]. AIDS, 2010,24 (2) :323-325.
  • 8AABYE M G, RUHWALD M,PRAYGOD G,et al. Potential of interferon- /- inducible protein 10 in improving tuberculosis di- agnosis in HIV- infected patients [ J ]. Eur Respir J, 2010,36 (6) : 1488-1490.
  • 9赵亚军,谭波.糖尿病合并肺结核病的临床探讨[J].中国现代医生,2009,47(13):139-140. 被引量:11
  • 10邓向斌,黄利荣,谢丹,李研,刘志辉,赖小敏,谭守勇.应用四聚体技术检测肺结核患者外周血及病变组织C5特异性CD4^+T细胞[J].实用医学杂志,2012,28(13):2181-2184. 被引量:2

引证文献4

二级引证文献10

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部