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优化全身照射技术对造血干细胞移植后发生间质性肺炎影响的初步观察 被引量：5

Effects of modified TBI technique on interstitial pneumonia after hematopoietic stem cell transplantation
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摘要 目的:探讨优化医用直线加速器高能X线全身照射(total body irradiation,TBI)的技术对造血干细胞移植后发生间质性肺炎(IP)的影响。方法:28例患者接受以环磷酰胺(CY)+全身放疗±依托泊苷(Vp-16)为预处理方案的造血干细胞移植,TBI采用分割放疗、肺挡铅技术,其中19例患者采用热释光剂量片(TLD)监测全身放疗的肺吸收剂量,TBI总量12Gy,共6次,肺部剂量8.5Gy。结果:28例患者随访24~104个月,中位随访时间75个月,5年总生存率(OS)为(53.6±9.4)%,5年无复发生存(RFS)(71.1±8.6)%;19例接受热释光剂量片监测吸收剂量的患者,肺吸收中位剂量8.44Gy,脐部吸收中位剂量11.87Gy,全身剂量的不均匀性<±10%;28例患者无1例发生IP。结论:采用分割全身放疗、肺挡铅、并用热释光剂量片监测肺吸收剂量可降低IP的发生。 OBJECTIVE:To investigate the effect of modified technique of total body irradiation (TBI) with high energy X-ray of accelerator on interstitial pneumonia after hematopoietic stem cell transplantation(HSCT). METHODS:Twenty-eight consecutive patients received HSCT. All the patients received CY+TBI±Vp-16 as conditioning regimen. The combination of fractionated TBI and lung blocks were used in all 28 patients to minimize IP as TBI techniques (TBI total dose to 12 Gy, 2 Gy twice a day for 3 days,lung dose to 8.5...
作者 许赪 张毅斌 胡炯 吴文 金冶宁
机构地区 上海交通大学医学院瑞金医院肿瘤放化疗科 上海交通大学医学院瑞金医院血液科
出处 《中华肿瘤防治杂志》 CAS 2008年第9期690-692,698,共4页 Chinese Journal of Cancer Prevention and Treatment
关键词 白血病/放射疗法 肺疾病 间质性 全身照射 造血干细胞移植 leukemia/radiotherapy lung diseases interstitial whole-body irradiation hematopoieticstam cell transplantation
分类号 R563.1 [医药卫生—呼吸系统]
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参考文献6

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二级参考文献10

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共引文献2

同被引文献24

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引证文献5

二级引证文献8

中华肿瘤防治杂志
2008年 第9期

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