局部晚期乳腺癌CEF序贯NP方案新辅助化疗的临床观察

Sequential treatment of CEF and NP regimen as a neodajuvan chemotherapy for locally advanced breast cancer

目的:了解CEF序贯NP方案新辅助化疗在局部晚期乳腺癌治疗中的疗效和毒副反应。方法:38例ⅡB期~ⅢB期的局部晚期乳腺癌患者术前接受新辅助化疗,CEF方案环磷酰胺(CTX)500mg/m2,d1,静脉注射;表柔比星(EPI)60mg/m2,d1,静脉注射;5-氟尿嘧啶(5-FU)500mg/m2,d1,持续4h静脉滴入,21d为1个周期,共3个周期后接受NP方案:诺维苯(NVB)25mg/m2,静脉推注,d1、d8;顺铂(DDP)30mg/m2,静脉滴入,d1~d3,并适量水化,每21d为1个周期,共3个周期。分别观察新辅助化疗后肿瘤原发病灶和区域淋巴结的缓解情况,以及毒副反应。结果:原发病灶临床有效率为92.1%(35/38),其中CR63.2%(24/38),PR28.9%(11/38),SD7.9%(3/18);pCR为31.6%(12/38)。22例化疗前细针穿刺活检明确区域淋巴结转移阳性的患者中,8例(36.4%)术后病理腋淋巴结转移阴性。毒副反应主要为白细胞减少症、脱发和恶心/呕吐,共有30例(78.9%)患者发生了Ⅲ~Ⅳ度的白细胞减少症。结论:CEF序贯NP新辅助化疗方案在局部晚期乳腺癌的治疗中...

OBJECTIVE:To evaluate the effect and toxicities of sequential treatment of CEF and NP regimen as a neodajuvan chemotherapy for locally advanced breast cancer. METHODS: The data of 38 cases of locally advanced breast cancer from stage ⅡB to stage ⅢB was studied. Patients in the group received 3 cycles of CEF regimen (cyclophosphamide, 500 mg/m2, d1, intravenous injection; Epirubicin, 60 mg/m2, d1, intravenous injection, Fluorouracil, 500 mg/m2, d1, intravenous drip about 4 hours, within 3 weeks), and then 3 ...