心肌梗死患者血清同型半胱氨酸、超敏C-反应蛋白、载脂蛋白E和血脂指标检测结果评价及相关性研究

Myocardia infarction patients with serum homocysteine,and high sensitive C-reactive protein,lipid and apolipoprotein E and related test results of the evaluation study

目的:评价心肌梗死患者血清同型半胱氨酸(HCY)、超敏C-反应蛋白(hs-CRP)、载脂蛋白E(ApoE)和血脂指标检测结果在临床方面的应用。方法:选择心肌梗死的患者73例,依据冠状动脉病变支数分为三组;单支血管病变组28例,双支血管病变组25例,三支以上血管病变组20例。另选取冠脉造影阴性患者28例和同期干部体检健康者29例为对照组。测定其血清总胆固醇(TCHO)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、载脂蛋白E(ApoE)、同型半胱氨酸(HCY)、超敏C-反应蛋白(hs-CRP)水平。结果:健康对照组、冠脉造影阴性对照组和冠脉病变组之间TCHO、HDL-C、LDL-C和hs-CRP差异有统计学意义。TG、ApoE和HCY差异均无统计学意义。hs-CRP和HCY与血管病变支数呈正相关,HDL-C与血管病变支数呈负相关,ApoE与血管病变支数无相关性。结论:心肌梗死患者HDL-C降低,LDL-C、ApoE、HCY、和hs-CRP升高,且hs-CRP、HCY和HDL-C的水平与心肌梗死血管病变程度显著相关。

Objective:To evaluate myocardial infarction patients with serum homocysteine(HCY),high-sensitivity C-reactive protein(hs-CRP),apolipoprotein E(ApoE),and blood lipid test results in clinical indicators of the application.Methods:Patients with myocardial infarction in 73 cases,according to the number of coronary artery disease were divided into three groups;Single Support Group 28 cases of vascular lesions,two-group of 25 patients with vascular lesions,vascular lesions Group 3 above 20 cases.Another negative ...