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细胞毒T淋巴细胞相关抗原4基因多态性与乳腺癌易感性的关联研究 被引量：2

Association of cytotoxic T lymphocyte antigen-4 gene polymorphisms with susceptibility to breast cancer
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摘要 目的:探讨CTLA-4基因多态性位点-1722T/C和CT60G/A与中国北方汉族妇女乳腺癌易感性的关系。方法:采用聚合酶链反应(PCR)和限制性片段长度多态性方法,对328例中国北方汉族乳腺癌患者和327例正常对照者进行CT-LA-4基因-1722位点和CT60位点多态性检测。结果:乳腺癌患者CTLA-4基因CT60位点G等位基因频率在乳腺癌患者组中明显高于正常对照组(28.7%比23.5%;P=0.0352,OR=1.30,95%CI=1.02~1.67);-1722C-CT60A单体型在对照组中的频率大于病例组中的频率,有明显差异(P=0.0283,OR=0.77,95%CI=0.97~0.61),而在-1722位点基因型频率、等位基因频率与对照组比较差异无统计学意义(P>0.05)。结论:CTLA-4基因多态性-1722和CT60两个位点与我国北方汉族妇女乳腺癌发病存在一定的相关性。 AIM:To investigate the association between the CTLA-4 promoter-1722(T/C)and 3 untranslated region CT60(G/A)polymorphisms and the risk of breast cancer in Han women of northeast China.METHODS:328 patients with breast cancer and 327 healthy people as control were genotyped for-1722 and CT60 polymorphism using polymerase chain reaction and restriction fragment length polymorphism.RESULTS:The frequency of the G allele at the CT60 site in breast cancer patients was statistically higher than that in control(28.7...
作者 李恒 傅振坤 王丽虹 李大林 吴娜哈尔滨医科大学卫生微生物学教研室 章婕 李殿俊
机构地区 哈尔滨医科大学免疫学教研室 哈尔滨医科大学附属肿瘤医院 哈尔滨医科大学免疫学教研室 黑龙江哈尔滨 黑龙江哈尔滨
出处 《细胞与分子免疫学杂志》 CAS CSCD 北大核心 2008年第3期282-284,共3页 Chinese Journal of Cellular and Molecular Immunology
基金 黑龙江省科技厅攻关资助项目(GB05C402-03)
关键词 乳腺癌 CTLA-4基因 单核苷酸多态性 单体型 breast cancer CTLA-4 gene single nucleotide polymorphism haplotype
分类号 R737.9 [医药卫生—肿瘤]
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参考文献12

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二级参考文献19

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共引文献3

同被引文献17

  • 1宋继权,夏冰,李睿,李春,吴云华.胃癌与细胞毒性T淋巴细胞相关抗原-4基因启动子区域多态性的相关性研究[J].中华实验外科杂志,2006,23(11):1373-1374. 被引量：8
  • 2王彦波,吕明,张淑杰,黎燕.CTLA4及其单克隆抗体功能及应用研究进展[J].细胞与分子免疫学杂志,2007,23(6):587-589. 被引量：4
  • 3FORSTI A, LI X, WAGNER K, et al. Polymorphisms in the transforming growth factor beta 1 pathway in relation to color- ectal cancer progression [J] Genes Chromosomes Cancer, 2010,49 (3) .. 270-281.
  • 4HURWITZ A A, FOSTER B A, KWON E D, et al. Combi- nation immunotherapy of primary prostate cancer in a trans- genic mouse model using CTLA-4 blockade[J]. Cancer Res, 2000,60 : 2444-2448.
  • 5LANG C C, CHEN L, LI S L. Cytotoxic T-lymphocyte anti- gen-4-:-49G/A polymorphism and susceptibility to pancreatic cancer[J]. DNA Cell Biology, 2012,31(5) :683-687.
  • 6HADINIA A, HOSSIENI S V, ERFANI N, et al. CTLA-4 gene promoter and exon 1 polymorphisms in Iranian patients with gastric and coloreetal cancers[J]. Journal of Gastroenter ology and Hepatology, 2007,22(12) :2283-2287.
  • 7COZAR J M, ROMERO J M, APTSIAURI N, et al. High in- cidence of CTLA-4 AA (CT60) polymorphism in renal cell cancer[J]. Hum Immunol, 2007,68(8) :698-704.
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  • 9PRUOHIT S, PODOLSKY R, COLLINS C, et al. Lack of correlation between the levels of soluble cytotoxic T-lympho- cyte associated antigen-4 (CTLA-4) and the CT-60 genotypes [J]. Journal of Autoimmune Diseases, 2005,2:8.
  • 10杨军,陈明清,董坚.VEGF/VEGFR2信号转导通路在抗肿瘤血管生成中的作用[J].世界华人消化杂志,2007,15(34):3611-3616. 被引量：23

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细胞与分子免疫学杂志
2008年 第3期

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