期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

促炎细胞因子对肠上皮细胞紧密连接调控的分子机制 被引量：6

Molecule mechanisms of the pro-inflammatory cytokine's effect on intestinal epithelium tight junctions
下载PDF
导出
摘要 促炎细胞因子是由细胞分泌的、具有促进和调节炎性反应作用的小分子多肽,主要有IL-1、IL-6、肿瘤坏死因子-α(TNF-α)、γ-干扰素(IFN-γ)等。炎症性肠病病人血清中促炎细胞因子水平显著增高,并且能引起肠上皮细胞紧密连接的改变。现就促炎细胞因子对肠上皮细胞紧密连接调控的分子机制作一综述,旨在为开展基础研究和临床提供参考。 The pro-inflammation cytokine is secreted by cells,and the function is to promote and regulate inflammatory reactions.They include IL-1,IL-6,TNF-α and IFN-γ.Researchs have revealed that the levels of serum pro-inflammation cytokinemight increase notably in inflammatory bowel disease patients and they could cause the change of intestinal epithelium tight junctions.
作者 顾立立 李宁
机构地区 第二军医大学南京临床医学院(南京军区南京总医院)解放军普通外科研究所
出处 《肠外与肠内营养》 CAS 2008年第2期114-118,共5页 Parenteral & Enteral Nutrition
基金 南京军区医药科研项目重大专项资助(07Z026)
关键词 促炎细胞因子 肠上皮 紧密连接 分子机制 Pro-inflammation cytokine Intestinal epithelium Tight junctions Molecular mechanism
分类号 R574 [医药卫生—消化系统]
  • 相关文献

参考文献43

  • 1[1]Reinecker HC,Steffen M,Doehn C,et al.Proinflammatory cytokines in intestinal mucosa[J].Immunol Res,1991,10(3-4):247-248.
  • 2[2]Hayashi H,Onozaki K.[Interleukin-1 (IL-1) alpha,beta,IL-1 receptor,IL-1 receptor antagonist (IL-1ra)][J].Nippon Rinsho,2005,63(Suppl 8):60-64.
  • 3[3]Al-Sadi RM,Ma TY.IL-1beta causes an increase in intestinal epithelial tight junction permeability[J].J Immunol,2007,178(7):4641-4649.
  • 4[4]Wang L,Walia B,Evans J,et al.IL-6 induces NF-kappa B activation in the intestinal epithelia[J].J Immunol,2003,171(6):3194-3201.
  • 5[5]Atreya R,Neurath MF.Involvement of IL-6 in the pathogenesis of inflammatory bowel disease and colon cancer[J].Clin Rev Allergy Immunol,2005,28(3):187-196.
  • 6[6]Reinisch W,Gasche C,Tillinger W,et al.Clinical relevance of serum interleukin-6 in Crohn's disease:single point measurements,therapy monitoring,and prediction of clinical relapse[J].Am J Gastroenterol,1999,94(8):2156-2164.
  • 7[7]Tazuke Y,Drongowski RA,Teitelbaum DH,et al.Interleukin-6 changes tight junction permeability and intracellular phospholipid content in a human enterocyte cell culture model[J].Pediatr Surg Int,2003,19(5):321-325.
  • 8[8]Yang R,Han X,Uchiyama T,et al.IL-6 is essential for development of gut barrier dysfunction after hemorrhagic shock and resuscitation in mice[J].Am J Physiol Gastrointest Liver Physiol,2003,285(3):G621-G629.
  • 9[9]Desai TR,Leeper NJ,Hynes KL,et al.Interleukin-6 causes endothelial barrier dysfunction via the protein kinase C pathway[J].J Surg Res,2002,104(2):118-123.
  • 10[10]Sawai T,Drongowski RA,Lampman RW,et al.The effect of phospholipids and fatty acids on tight-junction permeability and bacterial translocation[J].Pediatr Surg Int,2001,17(4):269-274.

二级参考文献32

  • 1秦环龙,高志光.肠上皮细胞紧密连接在肠屏障中的作用研究进展[J].世界华人消化杂志,2005,13(4):443-447. 被引量：37
  • 2李晓芳.严重烧伤后胃肠道功能障碍的机制和防治[J].世界华人消化杂志,2006,14(9):888-893. 被引量：17
  • 3Ma TY.Intestinal epithelial barrier dysfunction in Crohn's disease.Proc Soc Exp Biol Med 1997;214:318-327
  • 4Suenaert P,Bulteel V,Lemmens L,Noman M,Geypens B,Van Assche G,Geboes K,Ceuppens JL,Rutgeerts P.Anti-tumor necrosis factor treatment restores the gut barrier in Crohn's disease.Am J Gastroenterol 2002;97:2000-2004
  • 5Hopkins AM,Walsh SV,Verkade P,Boquet P,Nusrat A.Constitutive activation of Rho proteins by CNF-1 influences tight junction structure and epithelial barrier function.J Cell Sci 2003;116:725-742
  • 6Van Deventer SJ.Tumour necrosis factor and Crohn's disease.Gut 1997;40:443-448
  • 7Ricart E,Panaccione R,Loftus EV,Tremaine WJ,Sandborn WJ.Infliximab for Crohn's disease in clinical practice at the Mayo Clinic:the first 100 patients.Am J Gastroenterol 2001;96:722-729
  • 8Rutgeerts P,Feagan BG,Lichtenstein GR,Mayer LF,Schreiber S,Colombel JF,Rachmilewitz D,Wolf DC,Olson A,Bao W,Hanauer SB.Comparison of scheduled and episodic treatment strategies of infliximab in Crohn's disease.Gastroenterology 2004;126:402-413
  • 9Hanauer SB,Feagan BG,Lichtenstein GR,Mayer LF,Schreiber S,Colombel JF,Rachmilewitz D,Wolf DC,Olson A,Bao W,Rutgeerts P.Maintenance infliximab for Crohn's disease:the ACCENT I randomised trial.Lancet 2002;359:1541-1549
  • 10Zeissig s,Bojarski C,Buergel N,Mankertz J,Zeitz M,Fromm M,Schulzke JD.Downregulation of epithelial apoptosis and barrier repair in active Crohn's disease by tumour necrosis factor alpha antibody treatment.Gut 2004;53:1295-1302

共引文献18

同被引文献56

引证文献6

二级引证文献19

肠外与肠内营养
2008年 第2期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部