儿童淋巴瘤病人贫血状况回顾性调查评估

Results of a large retrospective survey: defining the prevalence, incidence and prognostic stratification of anaemia in children lymphoma patient

目的本研究探讨儿童淋巴瘤病人贫血患病率、发病率及治疗模式,确定发生贫血的危险因素。方法回顾性分析318例淋巴瘤患儿的病史及随访资料,包括年龄、性别、肿瘤类型、肿瘤及贫血的治疗方式,WHO体力状态等,并以血红蛋白水平为基础进行统计检验。结果贫血患病率为52.75%。血红蛋白水平与WHO得分明显相关(P<0.001)。在调查过程中贫血发病率为38.8%,年龄越小发病率越高;仅47.3%的病人在调查过程中接受了贫血的治疗。在开始治疗时总体血红蛋白最低点水平为89g/L,与贫血有关的危险因素有初始血红蛋白水平低、女性、抵抗性疾病以及铂类药物化疗等。结论淋巴瘤病人贫血患病率及发病率高,生活质量较差,应重视其治疗及危险因素的确定。

Objective To determine the prevalence, incidence of anaemia and its treatment in children with non-Hodgkin s lymphoma (NHL), and Hodgkin s disease (HD), further assess its predictive factors. Methods Data for a total of 318 patients were analyzed; variables including age, gender, tumor type/stage, cancer and anemia therapy, WHO performance status were subject to statistic analysis based on hemoglobin (Hb) levels. Results Anemia prevalence rate at enrollment was 52.75% and Hb levels correlated significantly ...