卡马西平对癫痫患者脑脊液中5-羟吲哚类物质的影响

Effect of CBZ on serotonin and 5-hydroxy-indole aectic acid in cerebrospinal fluid in patients with primary epilepsy

目的研究原发性癫痫患者卡马西平治疗前后脑脊液中5-羟色胺(5-HT)和5-羟吲哚乙酸(5-HIAA)含量的变化,以期了解5-HT和5-HIAA与癫痫的关系。方法以80例患者为研究对象,癫痫患者40例,对照组40例。根据是否服用卡马西平,将40例癫痫患者分为治疗组和非治疗组。然后采取脑脊液标本,用高效液相色谱—荧光分析法测定脑脊液及血浆中5-HT和5-HIAA含量。结果治疗组与非治疗组比较,脑脊液中5-HT和5-HIAA含量差别均有统计学意义(P<0.01)。结论卡马西平能提高脑脊液中5-HT和5-HIAA含量。

Objective: To explore the relationship among 5-HT/5-HIAA in CSF,primary epilepsy.Methods: Eighty in-patients were collected and divided into the groups of the epilepsy and the control.The patients with epilepsy were divided into two groups of the treatment and untreatment groups.The levels of 5-HT/5-HIAA in plasma and CSF were all detected with fluorescence spectrophotometry in those groups.Results: Concentrations of 5-HT/5-HIAA in CSF were significantly different among the treatment and the untreatment gro...