联合检测血清CA153 CA125 CA199在乳腺癌早期诊断中的价值

Study on the Early Diagnostic Value of Combined Detection of CA153,CA125 and CA199 in Breast Cancer

目的:探讨血清CA153、CA125、CA199联合检测在乳腺癌早期诊断中的临床应用价值。方法:采用电化学发光免疫分析法(ECLIA)同时检测43例乳腺癌、48例乳腺良性疾病与50例正常健康体检女性的血清CA153、CA125、CA199水平。结果:乳腺癌组CA153、CA125、CA199水平均显著高于健康对照组与乳腺良性疾病组(P<0.01),乳腺良性疾病组CA153、CA125、CA199水平与健康对照组均差异无显著性(P>0.05)。CA153、CA125、CA199单独检测乳腺癌的灵敏度分别为58.14%,34.88%,27.91%,特异度为92.86%,89.80%,93.88%。三者联合检测乳腺癌的灵敏度为79.07%、特异度为85.71%。结论:血清CA153、CA125、CA199联合检测能提高乳腺癌早期诊断的诊断率。

Objective To evaluate the value of combined analysis of CA153,CA125 and CA199 in the early diagnosis of breast cancer.Methods Serum levels of CA153,CA125 and CA199 collected from 43 cases with breast cancer,48 cases with benign breast diseases and 50 healthy volunteers were determined in electro-chemiluminescent immunoassay(ECLIA) method. Results The concentration of CA153,CA125 and CA199 in the breast cancer group were higher than those in the benign breast diseases group and healthy volunteers group (P<...