孕激素治疗子宫内膜不典型性增生38例临床分析

Progestogen therapy of atypical hyperplasia of endometrium in patient over the age of 40:analysis of 38 cases

目的:探讨40岁以上子宫内膜不典型性增生患者孕激素治疗的临床意义。方法:子宫内膜不典型性增生患者38例,其中,轻度16例:采用醋酸甲羟孕酮10mg,3次/d,连服28d,月经第5天开始重复服药;中度15例:采用醋酸甲羟孕酮10mg,3次/d,连服3月;重度7例:采用甲地孕酮160mg,1次/d,连服3月。3个月为1疗程,完成1疗程后,行子宫内膜病检以指导治疗。轻、中度患者停止孕激素治疗后给予避孕药治疗3～6月。结果:治疗3疗程后缓解37例,月经周期正常、月经量少者25例,闭经者11例。结论:孕激素治疗子宫内膜不典型性增生疗效肯定,尤其对40岁以上渴望保留子宫、提高生活质量的患者意义重大。

Objective:To study the clinical significance of progestogen in curing atypical hyperplasia of endometrium(EAH)in patient over the age of 40.Methods:1.38 cases of EAH aged 40 or above were analyzed from Jun,2002 to Jun,2006.16 cases of light degree:oral application of Medroxyprogesterone Acetate,10 mg tid,started on the 5th day of menstruation and used continuously for 28 days;15 cases of midrange:used the same dose for three month;7 cases of weight degree:used dose of 160mg,qd,for three month.Three month wa...