HIF-1α MRP和P-gp在上皮性卵巢癌中的表达及其临床意义

Expressions of HIF-1α MRP and P-gp in and Its Epithelial Ovarian Cancer

目的探讨HIF-1α、MRP和P-gp在上皮性卵巢癌中的表达及其临床意义。方法运用免疫组织化学技术(S-P法)检测HIF-1α、MRP和P-gp在64例上皮性卵巢癌、20例交界性上皮性卵巢肿瘤和10例良性卵巢肿瘤组织中的表达。结果HIF-1α、MRP和P-gp三个指标在上皮性卵巢癌组织中阳性率分别为90.6%、92.2%和98.4%,显著高于交界性上皮性卵巢肿瘤和良性卵巢肿瘤(P<0.001);且HIF-1α、MRP和P-gp表达存在密切的相关关系(P<0.001);进行多因素logistic逐步回归分析,HIF-1α、MRP的共同表达与上皮性肿瘤不同类型之间具有统计学意义(P<0.001)。对生存的COX回归分析表明,临床分期、HIF-1α、MRP、淋巴结转移和残余灶5个因素对上皮性卵巢癌患者的预后有影响。结论上皮性卵巢癌中HIF-1α、MRP和P-gp阳性表达与临床化疗耐药有关,HIF-1α和MRP的表达影响患者的预后。联合检测3个指标对临床化疗疗效判断和患者预后估计具有积极的指导作用。

Objective To investigate the expressions its of HIF-1α、MRP and P-gp significance in epithelial ovarian cancer.Methods The means of immunohistochemisty(method of S-P) was used to detect the expressions of HIF1α,MRP and P-gp in 64 cases of epithelial ovarian cancer,20 cases of borderline epithelial ovarian tumor and 10 cases of benign epithelial ovarian tumor.Results The positive expressions of HIF-1α,MRP and P-gp in patients with epithelial ovarian cancer were 90.6%、92.2% and 98.4%,and all higher than those ...