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卵巢切除及雌二醇对大鼠腰椎松质骨微结构的作用及其生物力学性能的分析 被引量：4

Effects of Ovariectomy and Estradiol on Microarchitecture and Biomechanical Properties in Rat Vertebrae
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摘要 应用micro-CT获得腰椎松质骨微结构的三维参数,分析卵巢切除术与雌二醇干预对大鼠松质骨微结构及整体骨生物力学性能的作用,初步讨论松质骨微结构的改变对生物力学性能的影响。6月龄未交配雌性SD大鼠30只,随机分成3组(每组10只):假手术对照组(Sham)、去卵巢组(OVX)和去卵巢+补充雌二醇组(EBT)。术后相同条件饲养5个月,取第3腰椎进行生物力学压缩试验,第4腰椎行micro-CT扫描。结果表明,与相应的Sham组比较,OVX组的BV/TV、Tb.N均明显下降,Tb.Sp和SMI明显增高。EBT组的BV/TV、Tb.N和Tb.Th均大于OVX组,Tb.Th和SMI明显小于OVX组。骨力学性能检测显示OVX组腰椎松质骨E、Fmax和σmax均明显降低,而EBT组上述骨生物力学参数均明显改善。通过micro-CT获得的骨微结构参数并结合骨力学性能检测能为合理评价骨质疏松及抗骨质疏松药物药效研究提供较好的实验依据。 This study was aimed at observing the effects of ovariectomy and estradiol on the microarchitecture of cancellous bone and exploring the influence of microarchitectural change on the biomechanical properties.Thirty 6-month-old unmated female SD rats were randonmly divided into 3 groups(10 rat each): sham-operated control group (Sham), ovariectomized group (OVX)and Estradiol Benzoate treated group(EBT). All rats were housed in standard environmental conditions. Five months after operation, the rats were sacr...
作者 姚晓琳 贠晓非 陈天华 陈孟诗 何学令 龙维富 陈世前 李良
机构地区 四川大学华西医学中心生物医学工程研究室 四川大学口腔疾病研究国家重点实验室 四川大学力学系
出处 《生物医学工程学杂志》 EI CAS CSCD 北大核心 2008年第3期626-631,636,共7页 Journal of Biomedical Engineering
基金 国家自然科学基金资助项目(30770534 30270359)
关键词 卵巢切除术 雌二醇 微结构 micro-CT 生物力学特性 Ovariectomy Estradiol Microarchitecture micro-CT Biomechanical properties
分类号 R713 [医药卫生—妇产科学]
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参考文献11

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同被引文献34

  • 1FAN YuBo1,XIU KaiHua1,DONG Xiang2 & ZHANG Ming2 1 School of Biological Science and Medical Engineering,Beihang University,Beijing 100083,China,2 Department of Health Technology and Informatics,The Hong Kong Polytechnic University,Hong Kong,China.The influence of mechanical loading on osseointegration:an animal study[J].Science China(Life Sciences),2009,52(6):579-586. 被引量：3
  • 2李良,邓力,陈孟诗,吴文超,毛咏秋,陈槐卿.力学刺激对3月龄骨质疏松大鼠成骨细胞增殖与合成功能的影响[J].生物医学工程学杂志,2004,21(3):341-346. 被引量：9
  • 3董培智,曹丽梅,李波.去卵巢骨质疏松症大鼠模型骨密度的变化[J].动物学杂志,2004,39(6):87-90. 被引量：8
  • 4黄倩,徐丛剑.尼古丁抗雌激素作用的研究进展[J].国外医学（药学分册）,2006,33(3):204-207. 被引量：8
  • 5罗和古,丁杰,岳广欣,陈家旭.大鼠肝郁脾虚证的代谢组学研究[J].中西医结合学报,2007,5(3):307-313. 被引量：105
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生物医学工程学杂志
2008年 第3期

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