COX-2与MMP-7蛋白在胃癌组织中的表达及临床意义

The Clinical Significance and Expression of COX-2 and MMP-7 in Gastric Carcinoma

目的探讨环氧合酶-2(COX-2)和基质金属蛋白酶-7(MMP-7)蛋白在胃癌组织中的表达、相互关系及意义。方法应用免疫组化方法检测了82胃癌组织及30周边正常胃黏膜中COX-2和MMP-7的表达情况。结果COX-2蛋白在胃癌组织和周边正常胃黏膜组织中阳性表达率分别为63.4%和13.3%,胃癌组织中COX-2蛋白阳性率显著高于正常胃黏膜(P<0.001)。MMP-7蛋白在胃癌组织和周边正常胃黏膜组织中阳性表达率分别为73.2%和10%,胃癌组织中MMP-7蛋白阳性率显著高于正常胃黏膜(P<0.001)。COX-2的异常表达与肿瘤细胞分化程度、淋巴结转移、TNM分期显著相关(P<0.05)。MMP-7阳性表达率与淋巴结转移、TNM分期显著相关(P<0.001),而与肿瘤细胞分化程度无显著性相关(P>0.05)。胃癌组织中COX-2与MMP-7表达具有显著等级正相关(P<0.001)。结论COX-2与MMP-7表达与胃癌的生物学行为密切相关,且两者之间的表达强度具有显著等级正相关。COX-2与MMP-7可作为反映胃癌侵袭转移、判断预后的生物学指标。

Objective To investigate the expression of cyclooxygenase-2(COX-2) and matrixmetalloproteinase-7(MMP-7) in gastric carcinoma and study their relationship and clinical significance.Methods Expression of COX-2 and MMP-7 were examined with immnunohistochemical technique for specimens from 82 cases of gastric carcinoma and for sourrounding normal tissue from 30 cases.Results The positivity rate of COX-2 expression was significantly higher in gastric carcinoma than that in the normal tissue(63.4% vs 13.3%,P<0...