乙型肝炎病毒DNA定量与ALT的相关分析

Correlation Analyse between HBV DNA and ALT

目的探讨HBsAg+、HBeAg+、HBcAb+(简称"大三阳)"及HBsAg+、HBeAb+、HBcAb+(简称"小三阳)"乙型肝炎(简称"乙肝)"患者病毒DNA(HBV DNA)与ALT的相互关系。方法选择1191份乙肝患者血清标本(其中大三阳192例,小三阳999例),HBV DNA测定采用FQ PCR法,ALT检测采用酶法,对其检测结果进行分析。结果大三阳组和小三阳组HBV DNA与ALT值的差异均有高度统计学意义(P<0.01)。大三阳组HBV DNA异常率(91.67%)和ALT异常率(60.42%)显著高于小三阳组(21.62%、28.13%)(P<0.01),但HBV DNA与ALT并无相关性。结论大三阳患者HBV DNA含量及肝损伤程度高于小三阳患者,但HBV DNA与ALT并不相关,HBV DNA与ALT两者同时测定有助于更明确地反映患者体内病毒的感染情况。

Objective To investigate the correlation of HBV DNA and ALT in GroupⅠ(HBsAg+,HBeAg+,HBcAb+) and Group Ⅱ(HBsAg+,HBeAb+,HBcAb+) patients suffering from hepatitis B virus.Methods All the 1191 subjects(192 samples from GroupⅠ,999 samples from Group Ⅱ) underwent the determination of HBV DNA and ALT by FQ PCR and enzyme respectively,then its clinical significance was analized.Results Significant difference for both HBV DNA and ALT was existed between GroupⅠ and Group Ⅱ(P>0.01).Abnormity ratio of HBV DNA(91.67%...