促胰岛素释放肽和GLP-1类似物研究进展

Advances in Insulintropic Peptides and GLP-1 Analogs

近年来,从细菌、真菌等低等生物和爬行类、哺乳类等高等动物的体内,都发现存在着结构和功能相关、相似的促胰岛素释放肽或GLP-1类似物.目前国内外研究都在密切关注胰高血糖素样肽-1(glucagonl-ikepeptide-1,G LP-1)和G LP-1类似物等胰高血糖素家族肽,对其进行基因工程高效表达或通过组合化学方法修饰、改造,从而设计治疗Ⅱ型糖尿病的多肽类药物.但是,从天然生物体内,尤其是最近从两栖类动物皮肤分泌液中和响尾蛇毒素中发现了大量能稳定促进胰岛素释放的生物活性肽,却还没有受到足够的重视,它们将很可能为筛选和开发出安全、高效、半衰期长的治疗Ⅱ型糖尿病新药物提供全新的思路和广阔的前景.

Recently,large amounts of insulintropic peptides and GLP-1 analogs with similar or relating structures and functions have been found from various kinds of natural lives,ranging from simple bacterials and epiphytes to evolutional reptiles and mammalias.Right now,the GLP-1 and some GLP-1 analogs have been focused and researched by gene engineering expression and chemistry synthesizing modification to develop new peptidal drugs to treat type 2diabetes.However,other insulintropic peptides,especially those being...