抗癫痫药物对儿童脑电图影响的初步探讨

The Preliminary Exploration on Electroencephalogram with Drugs Resisted Epilepsy

目的探讨癫痫患儿应用卡马西平(CBZ)和丙戊酸钠(VPA)对脑电图的影响。方法对31例单独应用CBZ和35例单独应用VPA,临床发作缓解的两组病例进行脑电图(EEG)分析。结果CBZ组48.4%病人痫样放电减少或消失。22.6%痫样放电反而增加。VPA组80%病人痫样放电明显减少或消失。结论CBZ和VPA可使临床发作控制,但CBZ组却有22.6%的病人痫样放电增加,同时引起EEG背景活动慢化,表现为α活动减少,θ波增加,δ波增加,因此脑电图不能作为卡马西平治疗有效的一种指标。

Objective To explore the effect of carbamazepine(CBZ)and valproic(VPA)upon electroencephalogram(EEG)in epileptic children.Methods To analyse the electroencephalogram of two group patients.One group include 31patients treated with CBZ only and the other includes 35patient treated with VPA only.All of the patients were treated clinically.Results In CBZ therapy group,48.4% of the patients the interictal epileptiform discharges vanished or decreased and in VPA group 80% of the patients the interictal epileptifo...