表皮生长因子受体在膀胱癌非肿瘤黏膜中的表达及意义

Expression of epidermal growth factor receptor in normal bladder mucosa of patients with bladder cancer and its clinical significance

目的探讨膀胱癌非肿瘤黏膜表皮生长因子受体(EGFR)表达与膀胱癌预后的关系。方法1998-2004年原发性膀胱癌患者非肿瘤黏膜组织标本64例,标本均为距癌组织至少3cm以上病理证实为正常膀胱黏膜;另6例正常膀胱黏膜均取自良性前列腺增生手术患者。采用S-P免疫组化染色,对检测结果进行统计学分析处理(χ2检验)。结果随膀胱肿瘤病理分级增加,EGFR表达阳性表达率增高,Ⅲ级明显高于Ⅰ级和Ⅱ级(χ2=6.22,P<0.05);EGFR表达随肿瘤临床分期的增加阳性表达率也增高,但差异无统计学意义(χ2=2.08,P>0.05);复发性肿瘤EGFR阳性表达率明显高于未复发者,差异有统计学意义(χ2=4.95,P<0.05)。结论膀胱癌患者非肿瘤黏膜EG-FR表达较正常黏膜明显增强。EGFR在膀胱黏膜的异常表达可能早于癌细胞的出现,EGFR在膀胱肿瘤的发生、发展起着重要作用,可作为早期判断预后因子。

Objective To evaluate the relationship between expression of epidermal growth factor receptor (EGFR) in normal bladder mucosa of patients with bladder cancer and the prognosis of bladder cancer. Methods The hospital records of 64 patients treated with cystectomy or partial cystectomy for bladder cancer and 6 patients treated with prostatectomy for benign prostatic hyperplasia during 1998-2004 were reviewed.In every case of tumor on the bladder wall, the biopsy was taken at least 3 cm away from the neoplasm....