整合蛋白a5、β1亚基在膀胱移行细胞癌中的表达及临床意义

Correlation between Integrin a5,β1 subunit Expression in bladder transitional cell carcinoma and its clinical Implication

目的探讨整合蛋白a5、β1亚基在膀胱移行细胞癌中的表达及与肿瘤生物学行为的关系。方法采用免疫组织化学ABC法检测20例正常膀胱组织和20例膀胱移行细胞癌石蜡标本整合蛋白a5、β1亚基的表达水平,其中T16例,T28例,T36例;G17例,G26例,G37例。结果癌组织整合蛋白a5、β1亚基表达减弱或消失,其中a5亚基阳性率为55%,β1亚基阳性率为60%,正常膀胱组织中a5亚基阳性率为100%,β1亚基阳性率为95%,两者比较差异有统计学意义(P<0.05)。整合蛋白a5、β1亚基表达水平随膀胱癌病理分级升高而升高,随TMN分期的升高而降低。结论正常膀胱组织中整合蛋白a5、β1亚基表达高于膀胱移行细胞癌,其表达水平与膀胱癌的病理分级呈正相关关系,与临床分期呈负相关关系,整合蛋白a5、β1亚基有望成为膀胱癌诊断的一项有价值的指标。

Objective To study the correlation between the expression of integrin a5,β1 subunit in Bladder Transitional Cell Carcinoma and its clinicopathological data including tumour grade and clinical stage(T_1 6 cases,T_2 8cases,T_3 6 cases;G_1 7cases,G_2 6cases,G_3 7cases). Methods Expression of integrin a5,β1 subunit were examined in 20 cases of Bladder Transitional Cell Carcinoma and 20 cases of normal bladder tissues by immunohistochemical technique. Results Expression of integrin a5,β1 subunit in Bladder Trans...