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以bcl-2/IgH为分子标志检测B细胞淋巴瘤微小残留病的研究进展

The study of minimal residual disease with bcl-2/IgH in B cell lymphoma
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摘要 bcl-2/IgH基因重排是B细胞淋巴瘤最为常见的染色体易位,以bcl-2/IgH基因重排为克隆标志开展微小残留病变检测,对疾病的分期、疗效评价、化疗方案的确定、预后判断、复发监测和移植物净化都有着重要的意义。随着分子生物学的不断发展,有效、敏感、准确、快速的检测手段不断出现,并且从定性逐步发展到定量,为临床工作进入量化阶段奠定基础。 The most frequent chromosome translocation in B cell lymphoma is bcl-2/IgH rearrangement, which can be used as the mark to detect the minimal residual disease(MRD). Detection of bcl-2/IgH rearrangement is helpful in staging diseases,estimating curative effect,selecting treatment protocols, judging prognosis,monitoring relapse and purging grafts. With the development of the molecular biology, effective, sensitive, exact and fast detection methods appear quickly, which provide the base for clinical work enter...
作者 杨红 张铀
机构地区 昆明医学院第二附属医院血液科
出处 《白血病．淋巴瘤》 CAS 2006年第4期310-313,共4页 Journal of Leukemia & Lymphoma
关键词 bcl-2/IgH基因重排 B细胞淋巴瘤 染色体易位 Chromosome translocation B cell lymphoma bcl-2/IgH rearrangement
分类号 R733.1 [医药卫生—肿瘤]
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白血病．淋巴瘤
2006年 第4期

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