树突状细胞在造血干细胞移植后重建及与临床结果的相关性

Recovery of dendritic cells after allogeneic hematopoietic stem cell transplantation and its relations with clinical outcomes

异基因造血干细胞移植后,供体树突状细胞(DCs)在受者体内逐步重建。DC1,DC2在宿主体内重建速度各异。一些内源或外源性因素影响DCs重建。异基因和自体造血干细胞移植各有自己的DCs重建规律,并与移植后临床结果如移植物抗宿主病(GVHD)、移植后感染(Infection)、移植物抗白血病(GVL)效应具有相关性。

After allogeneic hematopoietic stem cell transplantation, donor dendritic cells(DCs) are transferred with hematopoietic grafts and subsequently arise de novo. At the same time,functional DC may be generated from peripheral blood progenitors at all time points. The reconstitution of circulating DC subsets (DC1 and DC2) does differ significantly undergoing allogeneic transplantation. DC recovery is possibly influenced by some inner or outer factors. The kinetics of reconstitution of circulating DC subsets aft...