摘要
目的:研究蒙药肉蔻五味丸对大鼠心肌梗死细胞凋亡的影响。方法:大剂量异丙基肾上腺素(iso-prenaline,ISO)建立大鼠心肌梗死模型,分别给予肉蔻五味丸及卡托普利治疗,运用白蛋白-钴结合(ACB)实验观察蒙药对心肌缺血变性白蛋白的影响,采用TUNEL法观察蒙药对心梗大鼠心肌细胞凋亡的影响。结果:ISO所致心肌梗死可明显诱导大鼠心肌细胞发生凋亡,蒙药高剂量组可明显提高缺血变性白蛋白(ischemia modifiedalbumin,IMA)表达水平,明显抑制和阻断心肌细胞发生凋亡。结论:蒙药肉蔻五味丸可通过抑制心肌细胞凋亡从而保护梗死心肌。
To study the protective effect of Mongolian drug Roukou Wuwei pill on myocardial infraction.Method:Myocardial infraction models in rat were prepared by subcutaneous tissue injecting large dosage isoproterenol(ISO),then treated by Roukou Wuwei pill and captopril.Function of Mongolian drug on ischemia modified albumin(IMA) was observed by ACB method,effect of mongolian drug on cell apoptosis was observed by TUNEL method.Result:ISO induced myocardial infraction could cause evident myocardial cell apoptosis.Mon...
出处
《中国民族民间医药》
2006年第5期292-294,310,共4页
Chinese Journal of Ethnomedicine and Ethnopharmacy
基金
本课题获内蒙古医学院重大科技项目基金资助批准号:NY2003ZD011
