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亲环素A在心血管系统中的作用 被引量：6

Effect of Cyclophilin A in the Cardiovascular System
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摘要 亲环素A是一种在生物体内普遍存在的蛋白质,具有肽脯氨酰顺反异构酶活性,并作为一种分子伴侣,参与体内多种蛋白的成熟、折叠、活化、稳定及定位。亲环素A具有很多生物学功能,包括免疫调节、细胞生长、肿瘤发生和血管疾病。其中,它在心血管疾病中的作用涉及环孢霉素A和MAPK家族。本文就亲环素A在心血管系统中的作用作一综述。 Objective Cyclophilin A is a ubiquitous protein in the organism,which possess peptidel prolyl cis-trans isomersae activity,and also been identified as chaperones able to regulate many correlated biological process of many types proteins in vivo such as mature,folding,activation,stabilization and location.Cyclophilin A involves many biological functions including immune modulation,cell growth,tumorigenesis,and vascular disease.Among thesefunctions,effect of cyclophilin A in the cardiovascular system refers t...
作者 曹春芽 黄红林
机构地区 南华大学药物药理研究所
出处 《南华大学学报（医学版）》 2006年第5期650-653,共4页 Journal of Nanhua University(Medical Edition)
关键词 亲环素A 心血管 环孢素A MAPK 肽脯氨酰顺反异构酶 cyclophilin A cardiovascular cyclosporinA MAPK peptidel prolyl cis-trans isomersae
分类号 R54 [医药卫生—心血管疾病]
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共引文献20

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南华大学学报（医学版）
2006年 第5期

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