整合素、诱导型一氧化氮合酶、肥大细胞在鼻息肉中的作用及相关性研究

STUDY ON THE ROLES AND RELATIONSHIP AMONG INTEGRIN、INDUCING NITRICOXIDE SYNTHASE AND MAST LEUKOCYTE IN NASAL POLYPS

结合国内、外近年来有关鼻息肉研究成果,研究整合素、诱导型一氧化氮合酶、肥大细胞与鼻息肉之间的关系。从细胞内生物信号转导、细胞生成、血管生成的角度证实整合素、诱导型一氧化氮合酶及肥大细胞与鼻息肉的发生密切相关,类固醇激素通过抑制诱导型一氧化氮合酶、肥大细胞活性对鼻息肉有肯定的治疗效果。

To investigate the relationship among integrin,inducing nitricoxide synthase(iNOS)and mast leukocyte(MC)for exploring their effects in the pathogenesis of nasal polyps.Integrin、iNOS and MC are correlated with nasal polyps-genesis have been confirmed in bio-signal transduction、cytopoiesis and angiogenesis in nasal polyps-genesis,steroid hormone have therapeutic efficacy in nasal polyps through restrain activity of iNOS and MC.