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TGF-β1在胃癌的表达及与collagen家族基因、EGR1表达的关系 被引量：1

EXPRESSION OF TGF-β1 IN GASTRIC CARCINOMA AND ITS CORRELATION WITH COLLAGEN FAMILY GENES AND THE EXPRESSION OF EGR1
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摘要 TGF-β1在正常组织是一种肿瘤抑制因子,但在多种肿瘤组织TGF-β1表达增加。TGF-β1可以促进Collagen表达增加。TGF-β1是EGR1下游的调节因子。它们之间的相互作用在肿瘤形成中起了重要作用。 TGF-β1 is considered as a tumour inhibitor in normal tissute.But the expression of TGF-β1 is increased in many tumour tissues.TGF-β1 can stimulate fibroblasts to proliferate,migrate and produce collagen.TGF-β1 can activate expression of TGF-β1.The interaction between them is very important in the formation of tumor.
作者 姜彩虹 刘淑萍 吕有勇
机构地区 内蒙古医学院生物化学教研室
出处 《内蒙古医学院学报》 2006年第S1期62-64,共3页 Acta Academiae Medicinae Neimongol
关键词 TGF-Β1 COLLAGEN EGR1 肿瘤 TGF-β1 Collagen EGR1 Cancer
分类号 R735.2 [医药卫生—肿瘤]
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参考文献10

  • 1Steiner MS,Barrack ER.Transforming growth factor-be-ta 1 overproduction in prostate cancer:effacts on growth invivo and in vitro[].Journal of Molecular Endocrinology.1992
  • 2Mora GR,Olivier KR,Mitchell RF Jr,et al.Regulationof expression of the early growth response gene-1(EGR-1)in malignant and benign cells of the prostate[].Prostate.2005
  • 3Wong WK,Ou XM,Chen K,et al.Activation of humanmonoamine oxidase B gene expression by a protein kinaseC MAPK signal transduction pathway involves c-Jun andEgr-1[].Journal of Biological Chemistry.2002
  • 4Mitchell A,,Dass CR,Sun LQ,et al.Inhibition of humanbreast carcinoma proliferation,migration,chemoinvasionand solid tumour growth by DNA zymes targeting the zincfinger transcription factor EGR-1[].Nucleic Acids Research.2004
  • 5Friess H,Yamanaka Y,Buchler M.Enhanced expressionof transforming growth factor beta isoforms in pancreaticcancer correlates with decreased survival[].Gastroenterology.1993
  • 6Li AG,Lu SL,Han G.Role of TGF-beta1 in skin in-flammation and carcinogenesis[].Molecular Carcinogenesis.2006
  • 7Sharma P,Veeranna,Sharma M,et al.Phosphorylationof MEK1 by cdk5/p35 down-regulates the mitogen-ac-tivated protein kinase pathway[].Journal of Biological Chemistry.2002
  • 8Krones-Herzig A,Adamson E,Mercola D.Early growthresponse 1 protein,an upstreamgatekeeper of the p53 tumorsuppressor,controls replicative senescence[].Proceedings of the National Academy of Sciences of the United States of America.2003
  • 9Okamura H,Yoshida K,Morimoto H et al.PTEN ex-pression elicited by EGR-1 transcription factor in caly-culin A-induced apoptotic cells[].Journal of Cellular Biochemistry.2005
  • 10Friedman E,Gold LI,klimstra D.High levels of tans-forming growth factor beta 1 correlate with disease progres-sion in human colon cancer[].Cancer Epidemiol Bio-makers Prev.1995

同被引文献17

  • 1俞清翔.转化生长因子β与肿瘤转移的研究进展[J].世界华人消化杂志,2006,14(25):2538-2541. 被引量：16
  • 2孔丽,姚树坤,马英,王容琦,张玉果.TGFβ1/Smads信号转导通路的变化在原发性肝癌发病机制中的作用[J].临床肝胆病杂志,2007,23(4):270-273. 被引量：4
  • 3Lyons RM, Moses HL. Transforming growth factors and the regulation of cell proliferation [ J ] . Eur J Biochem, 1990, 187 (3) : 467 - 473.
  • 4Moses HL, Yang EY, Pietenpol JA. TGF-beta stimulation and inhibition of cell proliferation : new mechanistic insights[ J ]. Cell, 1990,63 (2) : 245 - 247.
  • 5Cheifetz S, Weatherbee JA, Tsang ML, et al. The transforming growth factor-beta system, a complex pattern of cross-reactive ligands and receptors. (J) Cell,1987,48(3) :409 -415.
  • 6Aasbo V, Raeder J C, Groqaard B, et al. No additional analgesic effect of intra-articular morphine or bupivacaine compared with placebo after elective knee arthroscopy [ J ]. J Biol Chem, 1996,40 (5) :585 - 588.
  • 7Liu YP, Liu J, Palmiter RD, et al. Inhibitory effects of two oligosaccha- rides on murine melanoma experimental liver metastasis [ J ]. Letters Biotechnol, 1996,9 ( 3 ) : 198.
  • 8Pran KD, Hardd L M. STRAP and smad7 synergize in the inhibition of transforming growth factorβ signaling [J]. Molecular and cellular biology,1997,20(9) :3157-3167.
  • 9Kleeff J, Ishiwata T, Maruyama H, et al. The TGF-β signaling inhibitor smad7 enhances tumorigencity in pancreatic cancer [ J ]. Oncogene, 1999,18(39) :5363 -5372.
  • 10Torbenson M, Marinopoulos S, Dang DT, et al. Smad4 overexpression in hepatocellular carcinoma is strongly associated with transforming growth factor beta Ⅱ receptor immunolabling [ J ]. Hum Pathol, 2002, 33 (9) :871 -876.

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内蒙古医学院学报
2006年 第S1期

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