超声背向散射积分评价糖尿病肾病的临床研究

Clinical study in assess of diabetic nephropathy with ultrasonic integrated backscatter

目的:探讨超声背向散射积分(IBS)技术对糖尿病肾病(DN)的诊断价值。方法:将临床确诊的2型糖尿病肾病患者分为3组。I组早期DNI,I组临床期DNI,II组终末期DN。测量肾实质及肾窦区IBS值,以二者之比为肾实质校正IBS值(IBS%),所得结果与正常对照组肾实质IBS%对比分析。结果:①I组各年龄段肾实质IBS%平均值较对照组无显著差异(P>0.05)。②II组40岁以下者,肾实质IBS%平均值较对照组明显升高(P<0.01);40～59岁及60岁以上组IBS%平均值较对照组明显升高(P<0.05)。③III组40～59岁及60岁以上者,肾实质IBS%平均值较对照组明显升高(P<0.01)。④40岁以下者II组较I组IBS%平均值明显升高(P<0.01)。⑤40～59岁及60岁以上者3组IBS%平均值逐渐升高,三者之间有明显差异(P<0.05),其中III组较I组及II组IBS%平均值明显升高(P<0.01)。结论:糖尿病肾病临床期及终末期肾脏超声背向散射积分IBS值与健康者显著不同I,BS技术为临床无创评价糖尿病肾病各期提供一种新的检测手段。

Objective: To assess the value of ultrasonic integrated backscatter in diabetic nephropathy(DN).Methods: All the confirmed cases and normal controls were divided into four groups: Group I,early DN,Group II,clinical DN,Group III,failure DN,Group IV,normal controls.Results: ①No significant of IBS% was found between all the patients in Group I and normal subjects.②In group II IBS% of all patients age less than 40 years old were significantly higher than normal subjects.③In Group III IBS% of patients age 40～59 ...