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颈动脉内中膜厚度和血流剪切力的相关性研究 被引量:2

Correlative study of intima-media thickness and wall shear stress in common carotid artery
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摘要 目的:探讨颈动脉内中膜厚度(IMT)和血流剪切力的关系。资料和方法:采用高分辨力声像仪测量20例健康人颈动脉内中膜厚度,其中男10例,女10例,平均年龄(34.3±10.6)岁。同时测量该处血管的血流剪切力(τm),具体计算公式:τm=η×4×VmFD。通过直线相关分析判定内中膜厚度和血流剪切力的关系。结果:20例健康人平均内中膜厚度为(0.68±0.06)mm,相应的平均血流剪切力为(12.2±3.4)dynesFcm2,二者呈明显负相关(y=0.8174-0.0117xr,=-0.67)。结论:本研究表明颈动脉内中膜厚度和血流剪切力呈负相关,证实血流剪切力可影响颈动脉内中膜厚度的变化,对预测早期动脉粥样硬化有一定意义。 Objective: To explore the relationship between intima-media thickness(IMT) and wall shear stress in common carotid artery.Materials and Methods: Intima-media thickness was measured by high resolution ultrasound in common carotid artery of 20 healthy volunteers,10 males,10 females,average age(34.3±10.6)y.Wall shear stress was calculated as the following equation: τm=η×4×Vm/D.Results: The mean IMT of common carotid artery was(0.68±0.06)mm,the mean τm was(12.2±3.4)dynes/cm2.The mean shear stress was inversely ...
出处 《中国临床医学影像杂志》 CAS 北大核心 2006年第S1期8-9,共2页 Journal of China Clinic Medical Imaging
关键词 颈动脉 超声检查 carotid arteries ultrasonography
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参考文献3

  • 1Girerd X,,London G,Boutourie P,et al.Remodeling of theradial artery in response to a chronic increase in shear stress[].Journal of Hypertension.1996
  • 2Nadaud S,Philippe M,Arnal JF,et al.Sustained increasein aortic endothelial nitric oxide synthase expression in vivo in amodel of chonic high blood flow[].Circulation Research.1996
  • 3Traub O,Berk BC.Laminar shear stress:mechanisms bywhich endothelial cells transduce an athero-protective force[].Arteriosclerosis Thrombosis and Vascular Biology.1998

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