二甲双胍治疗2型糖尿病合并非酒精性单纯性脂肪性肝病的疗效分析

Therapeutic effect of metformin on type 2 diabetes mellitus complicated with nonalcoholic fatty liver

目的观察二甲双胍治疗2型糖尿病合并非酒精性单纯性脂肪性肝病的疗效。方法选择初发2型糖尿病合并非酒精性单纯性脂肪性肝病患者86例,随机分成2组,治疗组(饮食疗法+运动疗法+二甲双胍)46例,对照组(饮食疗法+运动疗法)40例。两组均予饮食疗法+运动疗法,在此基础上,治疗组口服二甲双胍500 mg,3次/d,疗程4个月。治疗前后查两组患者空腹血糖、餐后2 h血糖、谷丙转氨酶、谷草转氨酶、体重指数、甘油三酯、总胆固醇、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇、肝/脾CT比值。结果与对照组比,治疗组空腹血糖、餐后2 h血糖、谷丙转氨酶、谷草转氨酶、体重指数、甘油三酯、总胆固醇、低密度脂蛋白胆固醇降低(P<0.05),高密度脂蛋白胆固醇、肝/脾CT比值升高(P<0.05)。结论二甲双胍治疗2型糖尿病合并非酒精性单纯性脂肪性肝病有一定疗效。

Objective To assess the effect of metformin on type 2 diabetes mellitus complicated with nonalcoholic fatty liver.Methods Eighty-six patients with type 2 diabetes mellitus complicated with nonalcoholic fatty liver were randomized into treatment group(n=46) and control group(n=40).Two groups were treated with diet control and improving physical activity respectively for 4 months.Patients in treatment group took 500 mg metformin orally,3 times/d.Serum glucose,serum transaminase,body mass index,blood lipid and liver/spleen CT ratio were detected pre-and post-treatment respectively.Results The levels of FBG,2 h PBG,ALT,AST,BMI,TG,TC,LDLC in treatment group were significantly lower than those of the control group(P<0.05),but the HDL-C and liver/spleen CT ratio were significantly higher than those of control group(P<0.05).Conclusion Metformin is an effective remedy for type 2 diabetes mellitus complicated with nonalcoholic fatty liver.