对溴联苯合成工艺研究

A Study on the Synthesis of 4-Bromobiphenyl

采用定向催化技术催化联苯的溴化反应,并使用氯气替代一部分液溴,可以自由控制反应的发生和停止,有效地抑制邻位溴代和二溴取代副产物的产生。粗产品经减压精馏和重结晶,产品含量≥98%。

4-Bromobiphenyl was synthesized by bromination of biphenyl using an orientation catalyst.The occur and stop of the reaction was easily controlled by using chlorine in stead of parts of bromine,and 2-bromo biphenyl and 4,4′-dibromo biphenyl as by-products were effectively inhabited.