胺碘酮联合^(131)I治疗伴发房颤Graves病的临床比较研究

Clinical comparative study on the effect of amiodarone combined with ^(131)I on Graves disease complicated with atrial fibrillation

目的研究胺碘酮联合131I治疗伴发房颤的G raves病的疗效。方法48例伴发房颤的G raves病患者随机分为两组,每组各24例,131I治疗后2天分别给予胺碘酮和心得安,观察131I治疗后15 d、30 d、90 d的FT3、FT4水平和脉搏次数及房颤例数。结果131I联合胺碘酮组15 d、30 d后的FT3、FT4水平较131I联合心得安组显著降低(P<0.05),房颤人数显著减少(P<0.05)。结论胺碘酮联合131I治疗伴发房颤的G raves病有较好的疗效。

Objective To evaluate the role of amiodarone combined with ^(131)I in Graves disease complicated with atrial fibrillation. Methods 48 patients with Graves disease complicated with atrial fibrillation were divided into 2 groups randomly.24 cases were treated with amiodarone(the amiodarone group) and the others were treated with propranolol(the propranolol group) respectively after two days when all patients were treated by ^(131)I,and FT3、FT4、 pulse and cases complicated with atrial fibrillation were detected or measured in 15days 30days 90days after they were treated by ^(131)I. Results FT3、FT4、pulse and cases complicated with atrial fibrillation were significantly lower in the amiodarone group than those in the propranolol group in 15days,30days and 90days after they were treated by ^(131)I(P<0.05,P<0.05,P<0.05). Conclusion Amiodarone combined with ^(131)I is a better treatment in Graves disease complicated with atrial fibrillation.