D-泛醇的合成

Synthesis of D-panthenol

以D,L-泛解酸内酯、碳酸胍、氢氧化钙为原料,合成D,L-泛解酸胍,收率91.6%。D,L-泛解酸胍在甲醇溶液中拆分制备D-泛解酸胍和L-泛解酸胍,D-泛解酸胍与硫酸通过水解反应制得D-泛解酸内酯,收率92.3%。D-泛解酸内酯与3-氨基丙醇缩合制备D-泛醇,收率约100%。L-泛解酸胍通过消旋化、内酯化为D,L-泛解酸内酯,收率86.5%。拆分剂胍通过回收,实现了循环使用。通过IR、元素分析对产物进行了表征。

Guanidine D,L-pantoate was synthesized from D,L-pantolactone,guanidine carbonate and calcium hydroxide in a yield of 91.6%.Guanidine D-pantoate and Guanidine L-pantoate were separated from guanidine D,L-pantoate in methanol.Guanidine D-pantoate was hydrolyzed with sulfuric acid to D-pantolactone with a yield of 92.3%.D-Panthenol was synthesized from D-pantolactone and 3-aminopropanol with a yield of close to 100%.Guanidine L-pantoate was racemised to D,L-pantolactone with a yield of 86.5%.The resolution agent of guanidine can be reused.The structure of the product was identified by IR and elementary analysis.