摘要
目的研究克林霉素磷酸酯注射液与盐酸氨溴索注射液的配伍稳定性。方法用生理盐水将克林霉素磷酸酯注射液与盐酸氨溴索注射液混合,放置6h,观察外观、PH值变化,并以旋光法测定克林霉素磷酸酯的含量,用紫外分光光度法测定盐酸氨溴索的含量,观察配伍液含量的变化。结果两药配伍液在6h内外观,含量,PH值均无明显变化。结论6h内两药配伍稳定,性质无明显改变。
Objective To study the compatible stability of Clindamycin Phosphate Injection and Ambroxol Hydrochloride Injection in the Sodi-um Chloride Injection.Methods The contents were determined after mixing of Clindamycin Phosphate Injection and Ambroxol Hydrochloride In-jection within 6 hours, and the appearance of the solution was observed and its PHvalue was determined. Polarimeter method was adopted in Clin-damycin Phosphate Injection and UV-spectro photometry method was adopted in Ambroxol Hydrochloride Injection.Results The compatibility of Clindamycin Phosphate Injection and Ambroxol Hydrochloride Injection had no significant change in the aspect ,PH,and content.Conclusion The Clindamycin Phosphate Injection could be combined with Ambroxol Hydrochloride Injection, and used within 6 h.
出处
《临床和实验医学杂志》
2006年第9期1305-1306,共2页
Journal of Clinical and Experimental Medicine
关键词
克林霉素磷酸酯
盐酸氨溴索
配伍
稳定性
Clindamycin Phosphate
Ambroxol Hydrochloride
Compatibility
Stability