异丙酚复合瑞芬太尼用于人工流产术麻醉镇痛效果观察

Evaluate the analgesic effect of propofol combined with refentanyl on the induced abortion

目的观察异丙酚复合瑞芬太尼用于人工流产术的镇痛效果。方法选择早孕妇女200例,分组各100例为异丙酚复合瑞芬太尼麻醉组(A组)及局麻组(B组)进行手术观察比较。结果A组、B组手术无痛率分别为100%和3%,两组差异有非常显著性(P<0.005),两组术中出血量无明显差异(P>0.05),A组术中宫颈松弛较B组显著(P<0.005),A组对手术过程中血压、呼吸、心率、血氧饱和度比较无统计学意义(P>0.05)。结论小剂量异丙酚复合瑞芬太尼静脉麻醉用于人工流产术镇痛效果确切,起效和消除都很快,无明显积蓄现象,苏醒后意识完全恢复,且对手术无记忆,还可抑制迷走神经反射,消除人工流产综合征,对循环、呼吸干扰小,安全性相对较高。

Objective To evaluate the analgesic effect of propofol combined with refentanyl on the induced abortion.Methods 200 cases of early pregnant were equally assigned into two groups with propofol combined refentanyl(Group A)and local anesthesia(Group B) respectively.Results Group A possessed higher ratio of no-pain(Group A vs Group B=100% vs 3%,P<0.005)and better cervix relaxation during operation(P<0.005). But in group A the blood pressure、the heart rate、breath rate、SaO2 and the amount of hemorrhage during and after operation showed no statistical difference compared with pre-operation(P>0.05).Conclusion Low doses of propofol combined with refentanyl produced reliable analgesic effect on induced abortion. Induction and elimination occurs rapidly without accumulation. Recovery of consciousness is completed without recall during operation. This regime inhibits reflex of vagus and eliminate the syndrome of induced abortion and produces less disturbing on respiration and circulation,so it is relatively safe and shoulsad be re-comended.