地氯雷他定治疗慢性荨麻疹临床疗效观察

Desloratadine for chronic idiopathic urticaria

目的观察地氯雷他定治疗慢性特发性荨麻疹的临床疗效。方法采用对照方法,用地氯雷他定对慢性荨麻疹治疗前后进行临床对比观察。结果共观察患者108例,治疗后第7天、第14天、第28天观察并记录受试者瘙痒程度、风团数量以及风团大小按4级评分法记分,结果总积分随着治疗时间延长而降低第7天为8.41±0.54,第14天下降为4.66±1.35,第28天下降为2.81±1.53,与治疗前比较差异有统计学意义(P<0.01),治疗1周总有效率为33.3%,治疗2周总有效率提高为68.5%,治疗4周总有效率提高为87.9%,三者之间比较χ2值等于42.63,P<0.005,存在显著性差异。结论地氯雷他定对治疗荨麻疹有显著性效果,且随着治疗时间的延长治疗有效率明显增加,值得在临床上选用。

Objective To investigate the effectiveness of desloratadine for chronic idiopathic urticaria.Methods 108 patients with chronic idiopathic urticaria were treated with desloratadine for 7 days, 14 days or 28 days.Results of therapy were evaluated. Results The response rates were as follows: one week 33.3%, two weeks 68.5% and four weeks 87.9%, the differences were significant(χ~2= 42.63 and P<0.005).Conclusion Desloratadine is an effective drug for the treatment of chronic idiopathic urticaria.