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Expression of metallothionein-3 gene associated with lung adenocarci-noma

Expression of metallothionein-3 gene associated with lung adenocarci-noma
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摘要 Objective:To explore the role of metallothionein-3 gene in lung adenocarcinoma. Methods:cDNA microarray and northern blots analysis were used to study the expression of metallothionein-3 in lung adenocarcinoma. Results: The results of cDNA microarray showed that metallothionein-3 gene was expressed highly to normal lung tissues at the average ratio of 7.8 (Cy5/Cy3) in lung adenocarcinoma tissues. Northern blots confirmed the ratio changes detected from the microarray. Conclusion: Metallothionein-3 may play an important role in the lung adenocarcinoma development. Objective: To explore the role of metallothionein-3 gene in lungadenocarcinoma. Methods: cDNA microarray and northern blots analysis were used to study theexpression of metallothionein-3 in lung adenocarcinoma. Results: The results of cDNA microarrayshowed that metallothionein-3 gene was expressed highly to normal lung tissues at the average ratioof 7.8 (Cy5/Cy3) in lung adenocarcinoma tissues. Northern blots confirmed the ratio changes detectedfrom the microarray. Conclusion: Metallothionein-3 may play an important role in the lungadenocarcinoma development.
作者 卢继忠 黄盛东 李继喜 季朝能 于伟勇 徐志云
机构地区 Cardiac-thoracic Department State Key Laboratory of Genetic Engineering
出处 《Journal of Medical Colleges of PLA(China)》 CAS 2006年第5期298-301,共4页 中国人民解放军军医大学学报（英文版）
关键词 METALLOTHIONEIN-3 LUNG ADENOCARCINOMA cDNA MICROARRAY NORTHERN blots metallothionein-3 lung adenocarcinoma cDNA microarray northern blots
分类号 R734.2 [医药卫生—肿瘤]
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参考文献12

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Journal of Medical Colleges of PLA(China)
2006年 第5期

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