新生儿缺氧缺血性脑病不同治疗方案临床观察

Clinical observation of different treatment on neonatal HIE

目的观察不同治疗方案治疗新生儿缺氧缺血性脑病(HIE)的临床疗效。方法采用总结对比分析,治疗方案分3组,Ⅰ组一般支持治疗;Ⅱ组复方丹参与胞二磷胆碱;Ⅲ组在Ⅱ组基础上加用血活素;比较3组主要临床表现消失时间,平均住院天数、治愈率、死亡率。结果Ⅱ组、Ⅲ组与Ⅰ组比较主要临床表现消失时间、平均住院天数、治愈率、死亡率均有差异,而Ⅱ组与Ⅲ组之间比较差异无统计学意义。结论综合治疗新生儿缺氧缺血性脑病对减轻临床症状,缩短疗程,降低死亡率有积极的促进作用。

Objective To observe the clinical effect of different treatment on neonatal hypoxic-ischemic enceplalopathy(HIE).Methods Summary-contrast analysis is taken. The treatments are classifed as three groups:Group Ⅰ,general supportive treatment;GroupⅡ,Danshen complex with the addition of cytidine diphosphate choline;groupⅢ,groupⅡ with the additon of cerebrolysin.To compare the duration of the main clinical manifestation,average hospitalization days,recovery rate and mortality among the three groups.Results Comparing Group Ⅱ and Group Ⅲ with Group Ⅰ,there were the differences in disappearing time of the main manirestation,averge hospitalization days,recovery rate and mortality.However there was no statistical difference between GroupⅡ and Group Ⅲ.Conclusion Comprehensive treatment on HIE has active promoting effect on alleviating clinical symptoms,shortening treatment course and reducing mortality.