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新疆博尔塔拉蒙古自治州哈萨克族胰岛素受体底物-1基因G972R多态性与原发性高血压关联

Association of the G972R polymorphism of IRS-1 with essential hypertension in Xinjiang kazakh group
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摘要 目的 研究哈萨克族胰岛素受体底物-1(IRS-1)G972R多态性同原发性高血压的关系.方法 抽取哈萨克族原发性高血压及正常对照测定身高、体重、收缩压、舒张压、空腹血糖、血浆胆固醇、甘油三脂.提取DNA,链式反应-限制性片段长度多态性(PCR-RFLP)技术测定IRS-1基因G972R多态性.结果 哈萨克族原发性高血压和正常人群IRS-1 G972R多态GR,GR基因型频率之间差异无显著性(0.97,0.04及0.97,0.03,X2＝0.240,P＞0.05);两组中G及R等位基因频率差异无显著性(0.98,0.02及0.99,0.01,P＞0.05).未发现GG,GR基因型间体重指数、血糖及血脂水平有显著性差异.结论 IRS-1基因G972R多态性可能与新疆博尔塔拉蒙古自治州哈萨克族原发性高血压无关.
作者 赵蕾 徐翀 敖由特 王坤 郭艳英 宋涛 格尔莉 武贵臻 陈艳 何秉贤
机构地区 新疆医科大学第一附属医院
出处 《现代保健（医学创新研究）》 2006年第5期3-5,共3页
关键词 哈萨克族 高血压病 胰岛素受体底物-1 基因 基因多态性
分类号 R596.2 [医药卫生—内科学]
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参考文献17

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二级参考文献24

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现代保健（医学创新研究）
2006年 第5期

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