摘要目的 观察阿乐(国产阿托伐他汀)和舒降之(辛伐他汀)治疗高血压左室肥厚的作用.方法 左右心室肥大病例88例,分为2组.治疗组口服阿乐或舒降之20mg/d,对照组常规用药.治疗前和治疗3个月后分别做心脏B型超声检查,对比分析两组治疗前后左心室重量指数(LVMI).结果 两组治疗前LVMI无明显变化(138.5±7.8 VS 137.9±12.3,P=0.2)治疗3个月后有明显差异.治疗组较对照组明显减轻(126.1±13 VS 132±16,P<0.05).结论 他汀能进一步减轻心肌重量.
1[1]Indolfi C,Dilorenzo E,Perrino C,et al.Hydroxy-methylglutaryl conezyme A reductase inhibitior simvastatin prevents cardiac hypertrophy induced by pressure overload and inhibits pzlras activation.Girculation,2002,106:2118~2124
2[2]Nickenig G,Baumer AT,Temury,et al.statin-sensitive dysregulated AT1 receptor function and density in hypercholedterolemic men.circulation,1999,100:2131~2134
3[3]kureishi y,luo z,shiojima I.et al.The HMG-COA reductase inhibitor simvastatin activates the protein kinase AKT and promotes angiogenesis in normocholesterolemic animals.Nat Med,2000,6:1004~1010
4[4]Luo JD,zhang WW,zhang GP,et al.Effects of simvastatin on left Ventricular hypertrophy and function in rats with aortic stenosis.Acta pharmacol sin,1999,20:345~348
5[5]Bauersachs J,Galuppo P,Fraccarollo D,et al.Improvement of left ventricular remodeling and funetion by hydroxymethylglutaryl coenzyme a reductase inhibition with cerivastation in rats with heart failure of myocardial infaction circulation,2001,104:982~985