利福喷汀治疗耐利福平肺结核80例临床疗效观察

Observation of treatment outcome of Rifapentine on 80 bacteria positive tuberculosis cases resistant to Rifampin

目的观察评价耐利福平结核分枝杆菌对利福喷汀的药敏情况和利福喷汀治疗耐利福平肺结核的疗效。方法将耐利福平80例肺结核患者分为2组,A组(40例)、B组(40例)分别用DEZThT和DEZThP方案治疗12个月。观察痰菌阴转、肺部病灶吸收及不良反应情况。结果痰菌阴转率:12个月末A、B组分别为55.0%和28.2%;胸部X线改善有效率:A、B组分别为57.5%和33.3%;A与B组差异均有显著性(P<0.05)。结论临床上利福喷汀治疗某些耐利福平肺结核病例仍有一定疗效。

Objective To observe and evaluate the drug susceptibility of Rifapentine on Rifampin resistant tuberculous(TB) bacterium and its treatment outcome on pulmonary TB with Rifampin resistance.?Methods Eighty cases of pulmonary TB with Rifampin resistance were randomly divided into group A and group B.Different treatment regimens as DEZThT and DEZThP were applied in group A(40 cases) and group B(40 cases) for 12 months respectively.The sputum negative conversion,the absorption of lung foci,and side effects or poor clinical response of patients were observed.?Result The sputum negative conversion rates were 55.0% in group A and 28.2% in group B after twelve months treatment respectively with significant difference((P<)0.05).Furthermore,the absorption rates of lung foci determined by X-ray were 57.5% in group A and 33.3% in group B with significant difference((P<)0.05).?Conclusion Our results demonst rate that Rifapentine is still effective in the treatment of Rifampin resistant pulmonary TB in clinical practice.