曲马多联合丙泊酚在拔气管导管的应用观察

Clinical Application of Tramadol and Propoxate in Tracheal Extubation

目的探讨曲马多联合丙泊酚预防拔气管导管的应激反应。方法60例ASAⅠ～Ⅱ级择期开腹手术患者,接受气管插管、静吸复合全麻。术毕后拔气管导管,随机分为A、B、C三组,每组20例,术毕停麻醉药物,A组静注丙泊酚,同时缓慢静推曲马多,B组单用异丙酚,方法及剂量同A组,C组注射生理盐水。待达到可接受的拔管标准时拔除气管导管。术毕前10分钟记录SBP、DBP、MAP、HR、RPP,拔管前后每隔2分钟记录上述参数。结果A组拔管前后,SBP、DBP、MAP、HR、RPP无明显差异(P>0.05),B组和C组上述参数显著性差异(P<0.05)。结论曲马多联合丙泊酚能有效降低拔气管导管的应激反应。

Objective To observe the effects of intravenous tramadol and propoxate on reducing stress response to emergence from tracheal extubation.Methods 60 cases of ASA I-II patients, which were scheduled for selective surgery of abdomen were randomly divided into three groups and received a standard general anesthesia consisting of fentanyl,propofol,rocuronium and isoflurane. After the operate, tramadol and propoxate (Group A),propoxate (Group B),the normal saline (Group C) were given respectively by I.V. injection. Postoperative tracheal extubation was performed when acceptable criteria was achieved. Non-invasive mean arterial pressure (MAP) ,heart rate (HR) and RPP were recorded at 2 min interval from the end of operation, Results Within the several minutes after extubation, In the Group A, the SBP,DBP,MAP,HR,RPP were no variation significantly (p>0.05), the Group B and C was more increased than before extubation in this parameter, and compared with Group A, it had a difference obviously (P<0.05).Conclusion Intravenous tramadol and propoxate can effectively relieve stress response to emergence from tracheal extubation.