机体对HPV L1免疫应答的研究进展

Immune responses to major capsid protein L1 of human papillomavirus

HPV L1相关的免疫应答是天然免疫和适应性免疫协同作用的结果,目前相关的研究已经渗入了免疫应答的全过程。天然免疫参与HPV L1诱导的免疫应答,但人们对它的认识仍然很有限。适应性免疫研究的进展主要体现在3方面:①识别阶段。HPV的相关抗原主要由DC和LC摄取、加工、处理,经胞质溶胶、交叉提呈两种提呈途径提呈给CD8+细胞并使其致敏。②增殖分化阶段。Th1和Th2细胞都有出现,表明HPV L1不仅介导体液免疫,也介导细胞免疫。③效应阶段。L1介导产生的IgG、IgA、IgM类抗体都有其特殊性。

The associated immune responses to HPV L1 are the synergetic result of innate immunity and adaptive immunity,and now the research of this field has extended into every part of immune response process.Innate immunity contributes to the immune responses to HPV L1,but now its knowledge is still very limited.On the contrary,the research of adaptive has got great achievement.It has been confirmed that in recognization phase,HPV associated antigens are mainly uptaken and processed by DC and LC,and then presents to naive CD8+ cells through cytosal and cross presentation pathways for priming the naive CD8+ cells.During the following phases of proliferation and differentiation,both Th1 and Th2 cells are differentiated,suggesting that HPV L1 can induce not only humoral immunity but also cellular immunity.In effector phase,the features of IgG,IgA,and IgM mediated by L1 have been further investigated.