摘要
IRAKs(Interleukin-1 receptor associated kinases,IRAKs)作为TIR信号通路的重要连接体,在调节机体的自身免疫中起着重要的枢纽作用。家族成员包括IRAK1、IRAK2、IRAKM和IRAK4,目前还鉴定出8个剪接异构体。其中IRAK1和IRAK4有激酶活性,通过与MyD88和TRAF-6连接成复合物启动TLRs/IL-1介导的信号途径;而IRAK2和IRAKM则无激酶活性,对通路起着负调节作用。本文从IRAK的分子特点、作用和机制、与其它因子间联系及相应剪接异构体作一综述。
Interleukin-1 receptor associated kinases(IRAKs) are pivotal adaptors in the TIR (Toll/IL-1 receptor) signaling pathway and play an central role in regulating innate immunity.IRAKs are including 4 members,which named IRAK1,IRAK2,IRAKM,and IRAK4.Recently,8 alternative splicing variants have been found in human and murine.IRAK1 and IRAK4 have kinase-activity and can start TLRs/IL-1 signaling pathway by binding with MyD88 and TRAF-6 respectively;IRAK2 and IRAKM are kinase-inactive and negatively regulate the pathway.We will introduce the molecular characteristic,mechanism,interaction with others factors,and alternative splice variants of IRAKs in this review.
出处
《免疫学杂志》
CAS
CSCD
北大核心
2006年第z1期76-79,共4页
Immunological Journal
基金
国家自然科学基金资助项目(30500463)
