摘要
MICA和MICB是MIC(MHC classⅠchain-related Gene)家族的功能性基因,属于非经典的HLA-Ⅰ类基因,且具有较高的多态性。它们只在正常的胃肠道上皮和大多数上皮性肿瘤细胞表达。MICA/B为NKG2D的配体,与NKG2D/DAP10结合,激活NK细胞等发挥免疫监视作用;并且发现MICA/B与某些自身免疫性疾病(如阿狄森氏病、白塞氏病等)存在一定的相关性。
MICA and MICB are functional genes in the family of MIC genes(MHC class I chain-related gene),which are non-typical HLA classⅠgenes and are highly polymorphism.Constitutive expression of MICA/B is limited to gut epithelium of normal tissue and epithelium cancer cell.As the NKG2D receptors,MICA/B can combine with NKG2D/DAP10 for activating immunosurveillance mechanism of NK cells.It also has been reported that MICA/B have correlation with some immunity diseases(Addision's disease,Behcet's disease,ect).
出处
《免疫学杂志》
CAS
CSCD
北大核心
2006年第z1期131-134,共4页
Immunological Journal