胃肠道间质瘤原发灶大小与预后的关系(附35例报告)

Prognostic significance of primary tumor size in gastrointestinal stromal tumor: report of 35 cases

目的:探讨胃肠道间质瘤(GIST)原发灶大小与预后的关系.方法:对35例GIST临床资料进行回顾性分析.35例行完全手术切除,分析术后1、3、5年的生存率及肿瘤直径＜5～10 cm和以肿瘤直径5 cm、10 cm为界的GIST患者的5年生存率.结果:术后复发转移8例,均死亡.术后1、3、5年生存率分别为97.12%、77.60%、67.26%.肿瘤直径＜5 cm、5～10 cm与≥10 cm GIST患者5年生存率分别为93.80%、84.40%和28.00%(P＜0.05),肿瘤直径＜5 cm与≥5 cm GIST患者5年生存率分别为93.80%、54.31%(P＜0.05),肿瘤直径＜10 cm与≥10 cm GIST患者5年生存率分别为87.70%、28.00%(P＜0.05).结论:GIST完全切除后,肿瘤原发灶大小是影响预后的独立高危因素,肿瘤直径≥5 cm的患者术后应加强随诊.

Objective: To analyze the prognostic significance of primary tumor size in gastrointestinal stromal tumors (GIST). Methods: The clinical data of 35 patients with GISTs were analyzed retrospectively. To study the overall survival rate at 1-, 3-and 5-year and the survival of three groups divided by 5 cm, 10 cm, 5～10 cm at 5- year. Results: The 8 GISTs died of recurrence and metastasis. The overall survival rate at 1, 3 and 5 year were 97.12%, 77.60% and 67.26% respectively. The 5-year survival rate for tumors <5 cm, 5～10 cm and ≥10 cm were 93.80%, 84.40% and 28.00% respectively (P<0.05). The 5-year survival rate for tumors <5 cm and ≥5 cm were 93.80% and 54.31% (P<0.05). The 5-year survival rate for tumors <10 cm and ≥10 cm were 87.70% and 28.00% (P<0.05). Conclusions: Tumor size was an independent prognostic factor in patients with GIST. Patients with tumor size more than 5 cm should be intensively followed-up.