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超声微泡携基因治疗现状及在中枢神经系统的应用前景展望

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摘要 　　超声微泡携基因治疗是当今医学研究的又一个热点,自1968年Gramiak首次报道超声造影剂的应用以来,其声学特性不断地为人们所认识并应用于实践中.超声造影剂最初被设计用于诊断,近年来研究表明其在治疗方面亦有很大的潜力.国内外学者研究发现,超声微泡造影剂可作为一种新型的基因转染载体,将表面粘附或内部包裹有目的基因的超声造影剂经静脉注射后,在靶细胞或组织给予一定条件的超声照射,可明显提高体内局部组织、细胞的基因转染和表达,实现药物的靶向导入和释放,已成为目前超声医学的研究热点,并为众多医学领域所关注.目前超声微泡携基因治疗的研究主要集中于心脏及血管,而在中枢神经的研究甚少,本文就目前超声微泡携基因治疗的现状作一简单总结并对其在中枢神经系统的应用前景进行展望.……
作者 李承科 霍钢
机构地区 重庆医科大学附属第一医院神经外科
出处 《重庆医科大学学报》 CAS CSCD 2006年第z1期40-42,共3页 Journal of Chongqing Medical University
分类号 R [医药卫生]
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参考文献22

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二级参考文献41

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重庆医科大学学报
2006年 第z1期

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