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ADMA在慢性肾脏疾病患者并发心血管疾病中的作用 被引量：1

The Role Of ADMA in Cardiovascular Complication of Patients in Chronic Kidney Disease
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摘要 目前发现在肾功能正常或轻-中度异常的慢性肾脏疾病(CKD)直至终末期肾功衰竭(ESRD)患者中心血管并发症(CVD)的发生及死亡率较普通人群明显升高,其原因可能与不对称二甲基精氨酸(ADMA)升高所致的内皮功能异常有关。新近开展的各项研究集中于在慢性肾脏疾病中ADMA的病理作用,探讨在高ADMA的患者中如何采取有效的干预措施来改善预后,以及评价使用血浆ADMA水平预测慢性肾脏疾病进展及其心血管并发症风险的价值。 Asymmetric dimethylarginine(ADMA) is associated with the morbidity and mortality of cardiovascular complications(CVD) in patients with chronic kidney disease(CKD),even the renal function is normal or mild to moderate abnormal.The correlation between ADMA and CVD may due to endothelium dysfunction.Nowadays a great amount of researches are focusing on the pathophysiologic role of ADMA,any therapy to reduce its level and its value on predicting kidney progression and cardiovascular complications in chronic kidney disease.
作者 施蓓莉 倪兆慧
机构地区 上海交通大学医学院附属仁济医院肾脏科
出处 《心血管病学进展》 CAS 2006年第z1期63-65,共3页 Advances in Cardiovascular Diseases
关键词 不对称二甲基精氨酸 慢性肾脏疾病 心血管并发症 asymmetric dimethylarginine chronic kidney disease cardiovascular complications
分类号 R692 [医药卫生—泌尿科学]
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参考文献12

  • 1[1]Vallance P,Leone A,Calver A,et al.Accumulation of an endogenous inhibitor of nitric oxide synthesis in chronic renal failure[J].Lancet,1992,339:572-575.
  • 2[2]McDermott JR.Studies on the catabolism of NG-methylarginine,NG,NG-dimethylarginine and NG,NG-dimethylarginine in the rabbit[J].Biochem J,1976,154:179-184.
  • 3[3]Lindner A,Charra B,Sherrard DJ,et al.Accelerated atherosclerosis in prolonged maintenance hemodialysis[J].N Engl J Med,1974,290:697-701.
  • 4[4]Kielstein JT,Boger RH,Bode-Boger SM,et al.Asymmetric dimethylarginine plasma concentrations differ in patients with end-stage renal disease:Relationship to treatment method and atherosclerotic disease[J].J Am Soc Nephrol,1999,10:594-600.
  • 5[5]Sladek T,Gerova M,Znojil V,et al.Morphometric characteristics of cardiac hypertrophy induced by long-term inhibition of NO synthase[J].Physiol Res,1996,45:335-338.
  • 6[6]Kuhlencordt PJ,Gyurko R,Han F,et al.Accelerated atherosclerosis,aortic aneurysm formation,and ischemic heart disease in apolipoprotein E/endothelial nitric oxide synthase double-knockout mice[J].Circulation,2001,104:448-454.
  • 7张卫茹,陶立坚,陈本美,熊燕,游运辉,陈立平.血清不对称性二甲基精氨酸浓度变化与慢性肾衰高血压相关性探讨[J].湖南医科大学学报,2002,27(2):133-134. 被引量：13
  • 8孙坚军.ADMA与肾脏病的心血管疾病[J].国际泌尿系统杂志,2004,24(S1):98-101. 被引量：1
  • 9[9]Valkonen VP,Laakso J,Paiva H,et al.Asymmetrical dimethylarginine(ADMA)and risk of acute coronary events:Does statin treatment influence plasma ADMA levels[J]?Atherosclerosis,2003,4(4)suppl:19-22.
  • 10[10]Boger RH,Bode-Boger SM,Brandes RP,et al.Dietary L-arginine reduces the progression of atherosclerosis in cholesterol-fed rabbits:Comparison with lovastatin[J].Circulation,1997,96(4):1282-1288.

二级参考文献38

  • 1Kielstein JT, Bode-Boger SM, Frolich JC, et al. Relationship of asymmetric dimethylarginine to dialysis treatment and atherosclerotic disease[J]. Kidney Int, 2001,59(suppl 78):S9-13.
  • 2Bode-Boger SM, Boger RH, Kienke S, et al. Elevated L-arginine/dimethylarginine ratio contributes to enhanced systemic NO production by dietary L-arginine in hypercholesterolemic rabbits[J]. Biochem Biophys Res Commun, 1996,219:598-603.
  • 3Wever R, Boer P. Nitric oxide production is reduced in patients with chronic renal failure[J]. Arterioscler Thromb Vasc Biol, 1999,19:1168-1172.
  • 4Wahbi N, Dalton RN. Dimethylarginines in chronic renal failure[J]. J Clin Pathol, 2001,54:470-473.
  • 5Vallance P, Lenone A, Calver A, et al. Accumulation of an endogenous inhibitor of nitric oxide synthesis in chronic renal failure[J]. Lancet, 1992,339:572-575.
  • 6Macallister RJ, Whitley GS, Vallance P, et al. Effects of guanidino and uremic compounds on nitric oxide pathways[J]. Kidney Int, 1994,45:737-742.
  • 7Marescau B, Nagels G, Possemiers I, et al. Guanidino compounds in serum and urine of nondialyzed patients with chronic renal insufficiency[J]. Metobolism, 1997,46:1024-1031.
  • 8Miyazaki H, Matsuoka H, Cooke JP, et al. Endogenous nitric oxide synthase inhibitor: A novel marker of atherosclerosis[J]. Circulation, 1999,99:1141-1146.
  • 9Peters H, Bopder WA, Noble NA. L-Arginine supplementtation increases mesangial cell injury and subseqent tissue fibrosis in experimental glomerulonephritis[J]. Kidney Int, 1997,55:2264-2273.
  • 10KuroseI,WolfR,GrishamMB ,etal.Effectsofanendogenousinhibitorofnitricoxidesynthesisonpostcapillaryvenules. American Journal of Physiology . 1995

共引文献12

同被引文献17

  • 1Levey AS,Beta JA,Coronado BE,et al. Controlling the epidemic of cardiovascular disease in chronic renal disease: what do we know? what do we need to learn? where do we go from here[J] ? Am J Kidney Dis,1998,32:853-906.
  • 2K/DOQI Clinical practice guidelines for chronic kidney disease : evaluation, classification and stratificatian[J]. Am J Kidney Dis ,2002,39 (suppl 1 ) :S1-S266.
  • 3Coresh J, Wei GL, McQuillan G, et al. Prevalence of high blood pressure and elevated serum creatinine level in the United States [ J ]. Arch Intern Med, 2001, 161 : 1207-1216.
  • 4Bakris GL, Hart P, Ritz E. Beta blockers in the management of chronic kidney disease[ J]. Kidney Int,2006,70 : 1905-1913.
  • 5Klein IHHT,Ligtenberg G,Neumann J,et al. Sympathetic nerve activity is inap- propriately increased in chronic renal disease[ J]. J Am Soc Nephrol,2003,14 : 3239-3244.
  • 6Klein IHHT,Ligtenberg G,Oey PL,et al. Sympathetic activity is increased in polyeystic kidney disease and is associated with hypertension [ J ]. J Am Soc Nephrol, 2001,12 : 2427 -2433.
  • 7di Bona GF. Neural control of the kidney : past, present, and future [ J ]. Hypertension,2003,41:621-624.
  • 8Ye S, Ozgur B, Campese VM. Renal afferent impulses, the posterior hypothalamus, and hypertension in rats with chronic renal failure [ J ]. Kidney Int, 1997, 51 : 722-727.
  • 9Klein IH, Ligtenberg G, Oey PL, et al. Enalapril and losartan reduce sympathetic hyperactivity in patients with chronic renal failure [ J ]. J Am Soc Nephrol,2003, 14:425-430.
  • 10Wolf G, Chen S, Han DC, et al. Leptin and renal disease [J]. Am J Kidney Dis,2002,39:1-11.

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心血管病学进展
2006年 第z1期

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