吸毒人群HGV、TTV重叠感染及其影响因素的研究

Study on Drug Abusers' HGV/TTV Superinfection and Affection Factors

目的了解吸毒人群中HGV、TTV重叠感染状况及其影响因素。方法采用现况研究,整群抽样法抽取某女性戒毒所和某男性戒毒所中的吸毒人员590名,通过问卷调查收集吸毒者的有关资料并采集血清标本。用ELISA法检测血清中抗-HGVIgG及抗-TTVIgG,并用SPSS12．0对数据进行统计分析。结果吸毒人员中HGV阳性率为8．81%,TTV阳性率为24．75%,二者重叠感染率为7．80%(46/590),男性、女性重叠感染率分别为2．44%和12．87%；经x^2检验,低文化程度组与高文化程度组HGV、TTV重叠感染分别为8．98%和5．29%,差异无显著性(P＞0．05)；注射吸毒组与非注射吸毒组HGV、TTV重叠感染率分别为8．86%和6．11%,差异无显著性(P＞0．05)；有婚外性行为和无婚外性行为的吸毒者HGV、TTV的重叠感染率分别为7．98%和7．19%,差异无显著性(P＞0．05)；扎耳环孔组和未扎耳环孔组的HGV、TTV的重叠感染率分别为12．03%和3．08%,差异有显著性(P＜0．01)。经Logistic回归分析,性别、文化程度低是HGV、TTV重叠感染的危险因素(OR=1．98)。结论吸毒人群是HGV、TTV重叠感染的高危人群,性别、文化程度低可能是吸毒人群中HGV、TTV重叠感染的危险因素,吸毒方式、性行为等与HGV、TTV的重叠感染率无显著相关性。

Objective To study drug abusers' HGV/TTV superinfection and affection factors.Methods Through a cross - sectional study,we recruited 590 cases from a female drug - relief reformatory and a male drug - relief reformatory.A structured questionnaire was designed to get the drug abusers' information.After the interview,serum samples were collected and ELISA was applied to detect anti - HGVIgG and anti - TTVIgG.Data were analyzed by the SPSS12.0 software.Results The total prevalence of HGV/TTV superinfection among the drug abusers was 7.80 % ( 46/590 ),the prevalence rates of male and female were 2.44 % (7/287) and 12.87 % (39/303) respectively.Via Chi - square test,the prevalence rates of HGV/TTV superinfection were different between low education level (8.98 % ) and high education level (5.29 % ),but the difference was not significant (P＞0.05);the prevalence rates of HGV/TTV superinfection among parenteral drug users and non- parenteral drug users were 8.86% (32/361) and 6.11% (14/229) respectively,and there was no significant difference between them (P＞0.05).The prevalence rates of HGV/TTV superinfection among those with and without a history of extramarital sex were 7.98 % (36/451) and 7.i 9 % (10/139) respectively,also no significant difference was existed (P＞0.05).The prevalence rates of HGV/TTV superinfection among those who with and without an earhole were 12.03 % (35/291 )and 3.08 % ( 11/299 ) re- spectively,there was a significant difference between them (P＜0.01).Through logistic regression analysis,gender and low education level were risk factors of the superinfection of HGV/TTV (OR = 1.98 ).Conclusion The drug abusers are the population at high risk for HGV/TTV superinfection.Gender and low education level may be the risk factors to the superinfec- tion of HGV/TTV.The prevalence of HGV/TTV superinfection of drug abusers has no significant correlation with drug use route and sexual behavior characteristics.