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非小细胞肺癌中S100A4和上皮钙粘蛋白的表达及意义 被引量：1

Expressions of S100A4 and E-cadherin in Non-small Cell Lung Cancer and Its Significance
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摘要 目的探讨非小细胞肺癌中S100A4和上皮钙黏蛋白(E-cad)的表达及意义。方法采用免疫组化SP法检测76例乳腺癌中S100A4,E-cad表达情况,分析二者的表达与临床病理特征之间的关系。结果S100A4的表达与组织学分级、淋巴结转移呈正相关(P＜0．01)。E-cad的表达与组织学分级、淋巴结转移呈负相关(P＜0．01)。结论非小细胞肺癌中S100A4的表达和E-cad的表达缺失与肿瘤的进展密切相关,是判断非小细胞肺癌生物学行为、预测转移趋势的有价值的指标。 Objective To explore the expressions of SI00A4 and E-cadherin in non - small cell lung cancer and its sig- nificance.Methods The expressions of S100A4 and E-cadherin in non-small cell lung cancer were assessed by using immunohistochemistry SP method.Correlation between the expressions and clinicopathological features was statistically ana- lyzed.Results The expression of S100A4 had positive correlation with histological grading and lymph node metastasis(P＜0.01).The expression of E-cadherin had negative correlation with histological grading and lymph node metastasis(P＜0.01).Conclusion The expression of S100A4 and loss of E-cadherin expression are both significantly associated with tu- mor progression in non-small cell lung cancer,which are the valuable markers in predicting biological behavior and trend of metastasis of non-small cell lung cancer.
作者 盛赠美 范松青 唐四元
机构地区 湖南省长沙市三医院 中南大学湘雅二医院 中南大学护理学院
出处 《实用预防医学》 CAS 2006年第6期1464-1466,共3页 Practical Preventive Medicine
关键词 非小细胞肺癌 S100A4基因 上皮钙黏蛋白 Non-small cell lung cancer S100A4 E-cadherin
分类号 R730 [医药卫生—肿瘤]
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参考文献9

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同被引文献15

  • 1诸兰艳,陈平,蒋云生.HIF-1α和VEGF在非小细胞肺癌组织中的表达及其与肿瘤血管生成的关系[J].中国现代医学杂志,2005,15(7):1017-1019. 被引量：32
  • 2朱志华,戎铁华,曾灿光,吴秋良,马芸,黄晓平,李宝江,张蓬原,赵进明,胡祎,张仕义,余辉,马国伟,张兰军,温浙盛,傅剑华,龙浩.Ⅰ～Ⅱ期非小细胞肺癌组织中VEGF的表达和微血管密度与预后的关系[J].癌症,2005,24(7):865-869. 被引量：10
  • 3罗良平,陈金城,张海伟,王惠华.肺鳞癌和肺腺癌c-erbB-2及bcl-2表达水平与其影像学表现相关性的初步探讨[J].临床放射学杂志,1997,16(1):21-24. 被引量：21
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  • 6Breemnes RM, Veve R, Gabrielson E, et al. High - thoughput tissuc microarray analysis used to evaluate biology and prognostic signicance of the E - cadherin pathway in non - small - cell lang cancer [ J ]. J Clin Oncol,2002,20(10) : 2417.
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  • 8Hofmann UB, Westphal JR, Vanmujien GN, et al. Matrix metalloproteinases in human melanoma[ J ]. J Invest Dermatol,2000, 115 (3) : 337 - 344.
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  • 10Suzuki M, Izasa T, Fujisawa T,et al. Expression of matrix metalloproteinases and tissue inhibilor of matrix metallop roteinses in Non - small lung cancer [ J ]. Invasion Metastasis, 1998 - 1999, 18 ( 3 ) : 134 - 141.

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实用预防医学
2006年 第6期

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